KEGG   DRUG: SolifenacinHelp
Entry
D08522                      Drug                                   

Name
Solifenacin (INN)
Formula
C23H26N2O2
Exact mass
362.1994
Mol weight
362.4647
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
ATC code: 
Chemical group: 
Activity
M3 muscarine receptor antagonist, selective, Anticholinergic
Target
muscarinic cholinergic receptor M3 [HSA:1131] [KO:K04131]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD08 Solifenacin
      D08522  Solifenacin (INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Solifenacin
    D08522  Solifenacin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M3
     Solifenacin
      D08522  Solifenacin (INN)
BRITE hierarchy
Other DBs
CAS: 
242478-37-1
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C1y C    22.5322  -14.8066
            2   C1x C    22.5322  -13.4035
            3   C1y C    21.3396  -15.5082
            4   C1x C    23.7950  -15.5082
            5   C1x C    23.2338  -14.5961
            6   C1x C    22.0411  -16.7008
            7   C1x C    24.4264  -16.7008
            8   N1y N    23.2338  -15.9992
            9   C1x C    16.4989  -12.7020
            10  C1x C    17.6915  -13.4035
            11  N1y N    17.6915  -14.8066
            12  C1y C    16.4989  -15.5082
            13  C8y C    15.2361  -13.4035
            14  C8y C    15.2361  -14.8066
            15  C8x C    14.0434  -15.5082
            16  C8x C    12.8508  -14.8066
            17  C8x C    12.8508  -13.4035
            18  C8x C    14.0434  -12.7020
            19  C8y C    16.4989  -16.9113
            20  C8x C    17.6915  -17.6128
            21  C8x C    17.6915  -19.0159
            22  C8x C    16.4989  -19.7175
            23  C8x C    15.2361  -19.0159
            24  C8x C    15.2361  -17.6128
            25  C7a C    18.8841  -15.5082
            26  O7a O    20.1469  -14.8066
            27  O6a O    18.8841  -16.9113
BOND        31
            1    13   9 1
            2     9  10 1
            3    10  11 1
            4    11  12 1
            5    12  14 1
            6     1   2 1
            7    13  14 2
            8    14  15 1
            9    15  16 2
            10   16  17 1
            11   17  18 2
            12   18  13 1
            13    1   3 1
            14   12  19 1 #Up
            15    1   4 1
            16    2   5 1
            17    3   6 1
            18    4   7 1
            19    5   8 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   24  19 1
            26    6   8 1
            27   11  25 1
            28    7   8 1
            29   25  26 1
            30   25  27 2
            31    3  26 1 #Down

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