KEGG   DRUG: D08522Help
Entry
D08522                      Drug                                   

Name
Solifenacin (INN)
Formula
C23H26N2O2
Exact mass
362.1994
Mol weight
362.4647
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
M3 muscarine receptor antagonist, selective;
Anticholinergic
Remark
ATC code: 
Target
muscarinic cholinergic receptor M3 antagonist [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD08 Solifenacin
      D08522  Solifenacin (INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Solifenacin
    D08522  Solifenacin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M3 [HSA:1131] [KO:K04131]
     Solifenacin [ATC:G04BD08]
      D08522  Solifenacin (INN)
BRITE hierarchy
Other DBs
CAS: 
242478-37-1
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C1y C    22.5322  -14.8066
            2   C1x C    22.5322  -13.4035
            3   C1y C    21.3396  -15.5082
            4   C1x C    23.7950  -15.5082
            5   C1x C    23.2338  -14.5961
            6   C1x C    22.0411  -16.7008
            7   C1x C    24.4264  -16.7008
            8   N1y N    23.2338  -15.9992
            9   C1x C    16.4989  -12.7020
            10  C1x C    17.6915  -13.4035
            11  N1y N    17.6915  -14.8066
            12  C1y C    16.4989  -15.5082
            13  C8y C    15.2361  -13.4035
            14  C8y C    15.2361  -14.8066
            15  C8x C    14.0434  -15.5082
            16  C8x C    12.8508  -14.8066
            17  C8x C    12.8508  -13.4035
            18  C8x C    14.0434  -12.7020
            19  C8y C    16.4989  -16.9113
            20  C8x C    17.6915  -17.6128
            21  C8x C    17.6915  -19.0159
            22  C8x C    16.4989  -19.7175
            23  C8x C    15.2361  -19.0159
            24  C8x C    15.2361  -17.6128
            25  C7a C    18.8841  -15.5082
            26  O7a O    20.1469  -14.8066
            27  O6a O    18.8841  -16.9113
BOND        31
            1    13   9 1
            2     9  10 1
            3    10  11 1
            4    11  12 1
            5    12  14 1
            6     1   2 1
            7    13  14 2
            8    14  15 1
            9    15  16 2
            10   16  17 1
            11   17  18 2
            12   18  13 1
            13    1   3 1
            14   12  19 1 #Up
            15    1   4 1
            16    2   5 1
            17    3   6 1
            18    4   7 1
            19    5   8 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   24  19 1
            26    6   8 1
            27   11  25 1
            28    7   8 1
            29   25  26 1
            30   25  27 2
            31    3  26 1 #Down

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