| Entry |
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| Name |
Sotalol (INN);
Darob mite (TN)
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| Formula |
C12H20N2O3S
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| Exact mass |
272.1195
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| Mol weight |
272.3638
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| Structure |
     |
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| Activity |
beta-Adrenergic blocking [DS: H00293]
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| Remark |
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| Comment |
Class III antiarrhythmic agent
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| Target |
voltage-gated potassium channel (KCNH2) blocker [HSA: 3757] [KO: K04905]; beta1-adrenergic receptor antagonist [HSA: 153] [KO: K04141]; beta2-adrenergic receptor antagonist [HSA: 154] [KO: K04142] |
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| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
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| Interaction |
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| Structure map |
| Antiarrhythmic drugs | | Potassium channel blocking and opening drugs |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA07 Sotalol
D08525 Sotalol (INN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Antiarrhythmics
Sotalol
D08525 Sotalol (INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
beta1-adrenergic receptor [HSA:153] [KO:K04141]
Sotalol [ATC:C07AA07]
D08525 Sotalol (INN)
beta2-adrenergic receptor [HSA:154] [KO:K04142]
Sotalol [ATC:C07AA07]
D08525 Sotalol (INN)
Ion channels
Voltage-gated cation channels
K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
voltage-gated potassium channel (KCNH2) [HSA:3757] [KO:K04905]
Sotalol [ATC:C07AA07]
D08525 Sotalol (INN)
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| Other DBs |
CAS: 3930-20-9 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 18
1 C8y C 24.1500 -17.9900
2 C1c C 25.3400 -18.6900
3 C8x C 24.1500 -16.5200
4 C8x C 22.8900 -18.6900
5 C1b C 26.5300 -17.9900
6 O1a O 25.3400 -20.0900
7 C8x C 22.8900 -15.8200
8 C8x C 21.7700 -17.9900
9 N1b N 27.7900 -18.6900
10 C8y C 21.7700 -16.5200
11 C1c C 28.9800 -17.9900
12 N1b N 20.5800 -15.8200
13 C1a C 30.1700 -18.6900
14 C1a C 28.9800 -16.5900
15 S4a S 19.3200 -16.5200
16 C1a C 18.1300 -15.8200
17 O3c O 20.5800 -17.2900
18 O3c O 18.2700 -17.2900
BOND 18
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 1
8 5 9 1
9 7 10 1
10 9 11 1
11 10 12 1
12 11 13 1
13 11 14 1
14 12 15 1
15 15 16 1
16 15 17 2
17 15 18 2
18 8 10 2
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