KEGG   DRUG: D08525Help
Entry
D08525                      Drug                                   

Name
Sotalol (INN);
Darob mite (TN)
Formula
C12H20N2O3S
Exact mass
272.1195
Mol weight
272.3638
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
beta-Adrenergic blocking [DS:H00293]
Remark
Same as: 
ATC code: 
Comment
Class III antiarrhythmic agent
Target
voltage-gated potassium channel (KCNH2) blocker [HSA:3757] [KO:K04905];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes  
 
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA07 Sotalol
      D08525  Sotalol (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Sotalol
    D08525  Sotalol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Sotalol [ATC:C07AA07]
      D08525  Sotalol (INN)
    beta2-adrenergic receptor [HSA:154] [KO:K04142]
     Sotalol [ATC:C07AA07]
      D08525  Sotalol (INN)
 Ion channels
  Voltage-gated cation channels
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2) [HSA:3757] [KO:K04905]
     Sotalol [ATC:C07AA07]
      D08525  Sotalol (INN)
BRITE hierarchy
Other DBs
CAS: 
3930-20-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    24.1500  -17.9900
            2   C1c C    25.3400  -18.6900
            3   C8x C    24.1500  -16.5200
            4   C8x C    22.8900  -18.6900
            5   C1b C    26.5300  -17.9900
            6   O1a O    25.3400  -20.0900
            7   C8x C    22.8900  -15.8200
            8   C8x C    21.7700  -17.9900
            9   N1b N    27.7900  -18.6900
            10  C8y C    21.7700  -16.5200
            11  C1c C    28.9800  -17.9900
            12  N1b N    20.5800  -15.8200
            13  C1a C    30.1700  -18.6900
            14  C1a C    28.9800  -16.5900
            15  S4a S    19.3200  -16.5200
            16  C1a C    18.1300  -15.8200
            17  O3c O    20.5800  -17.2900
            18  O3c O    18.2700  -17.2900
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   15  17 2
            17   15  18 2
            18    8  10 2

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