KEGG   DRUG: D08528Help
Entry
D08528                      Drug                                   

Name
Spiramycin embonate;
Cofamix STS (TN)
Formula
(C43H73N2O14R)x. C23H16O6
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, macrolide
Remark
ATC code: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA02 Spiramycin
      D08528  Spiramycin embonate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Spiramycin [ATC:J01FA02]
      D08528  Spiramycin embonate
BRITE hierarchy
Other DBs
CAS: 
67724-08-7
PubChem: 
NIKKAJI: 
KCF data Show

ATOM        89
            1   C1y C    18.6200  -29.2600
            2   C1y C    19.6700  -29.9600
            3   O2a O    17.5000  -29.9600
            4   C1y C    18.6200  -28.0000
            5   C1y C    20.8600  -29.2600
            6   N1c N    19.6700  -31.2200
            7   C1y C    16.3800  -30.5900
            8   O2x O    19.6700  -27.3700
            9   C1a C    17.5000  -27.3700
            10  C1y C    20.8600  -28.0000
            11  O1a O    21.9800  -29.9600
            12  C1a C    20.9300  -32.5500
            13  C1a C    18.6900  -32.5500
            14  C1x C    16.3800  -31.8500
            15  O2x O    15.2600  -29.9600
            16  O2a O    23.1000  -25.4100
            17  C1z C    15.2600  -32.5500
            18  C1y C    14.1400  -30.5900
            19  C1y C    19.6700  -21.7000
            20  C1y C    14.1400  -31.8500
            21  C1a C    14.3500  -33.7400
            22  O1a O    16.1700  -33.8800
            23  C1a C    13.0200  -29.9600
            24  C1y C    19.6700  -20.3700
            25  C1y C    18.5500  -22.4000
            26  O1a O    13.0200  -32.5500
            27  C1x C    18.4800  -19.7400
            28  C1b C    20.7200  -19.7400
            29  C1y C    18.5500  -23.7300
            30  O2a O    17.5000  -21.7700
            31  C1y C    18.4800  -18.4100
            32  C4a C    21.8400  -20.3700
            33  C1x C    17.3600  -24.3600
            34  C1y C    17.3600  -17.7800
            35  C1a C    19.6000  -17.7800
            36  O4a O    22.9600  -19.7400
            37  C7x C    16.1700  -23.7300
            38  C2x C    16.2400  -18.4100
            39  O2a O    17.3600  -16.5200
            40  O7x O    15.0500  -24.3600
            41  O6a O    16.1700  -22.4000
            42  C2x C    16.2400  -19.7400
            43  C1y C    13.8600  -23.6600
            44  C2x C    15.1200  -20.3700
            45  C1x C    13.8600  -22.2600
            46  C1a C    12.8100  -24.2900
            47  C2x C    15.1200  -21.7000
            48  C1a C    17.5000  -20.5100
            49  O2a O    19.6700  -24.4300
            50  R   R    19.6700  -25.6200
            51  C1y C    16.2400  -15.8900
            52  O2x O    16.2400  -14.5600
            53  C1y C    15.1200  -13.9300
            54  C1y C    14.0000  -14.5600
            55  C1x C    14.0000  -15.8900
            56  C1x C    15.1200  -16.5200
            57  C1a C    15.1200  -12.6700
            58  N1c N    12.8100  -13.5800
            59  C1a C    12.8100  -11.9700
            60  C1a C    11.6200  -14.6300
            61  C8x C    28.7700  -24.5000
            62  C8x C    28.7700  -25.8300
            63  C8x C    29.9600  -26.5300
            64  C8x C    31.1500  -25.8300
            65  C8y C    31.1500  -24.5000
            66  C8y C    29.9600  -23.8000
            67  C8y C    32.3400  -23.8000
            68  C8y C    32.3400  -22.4000
            69  C8y C    31.1500  -21.7700
            70  C8x C    29.9600  -22.4000
            71  C1b C    34.1600  -24.6400
            72  C8y C    35.7700  -23.8000
            73  C8y C    36.9600  -24.5000
            74  C8y C    38.1500  -23.8000
            75  C8x C    38.1500  -22.4000
            76  C8y C    36.9600  -21.7700
            77  C8y C    35.7700  -22.4700
            78  C8x C    36.9600  -25.8300
            79  C8x C    38.1500  -26.5300
            80  C8x C    39.3400  -25.8300
            81  C8x C    39.3400  -24.5000
            82  C6a C    31.1500  -20.3700
            83  O6a O    32.3400  -19.6700
            84  O6a O    29.9600  -19.6700
            85  C6a C    36.9600  -20.3700
            86  O6a O    35.7700  -19.6700
            87  O6a O    38.1500  -19.6700
            88  O1a O    33.5300  -21.7700
            89  O1a O    34.5800  -21.7700
BOND        95
            1    19  25 1
            2    20  26 1 #Up
            3    24  27 1
            4    24  28 1 #Down
            5    25  29 1
            6    25  30 1 #Down
            7    27  31 1
            8    28  32 1
            9    29  33 1
            10   31  34 1
            11   31  35 1 #Down
            12   32  36 2
            13   33  37 1
            14   34  38 1
            15   34  39 1 #Down
            16   37  40 1
            17   37  41 2
            18   38  42 2
            19   40  43 1
            20   42  44 1
            21   43  45 1
            22   43  46 1 #Down
            23   44  47 2
            24    8  10 1
            25   18  20 1
            26   45  47 1
            27   30  48 1
            28    1   2 1
            29    1   3 1 #Down
            30    1   4 1
            31    2   5 1
            32    2   6 1 #Up
            33    7   3 1 #Up
            34    4   8 1
            35    4   9 1 #Up
            36    5  10 1
            37    5  11 1 #Down
            38    6  12 1
            39   29  49 1 #Down
            40    6  13 1
            41   49  50 1
            42    7  14 1
            43    7  15 1
            44   51  39 1 #Up
            45   10  16 1 #Up
            46   14  17 1
            47   15  18 1
            48   19  16 1 #Down
            49   17  20 1
            50   51  52 1
            51   52  53 1
            52   53  54 1
            53   54  55 1
            54   55  56 1
            55   56  51 1
            56   17  21 1 #Down
            57   53  57 1 #Up
            58   17  22 1 #Up
            59   54  58 1 #Down
            60   18  23 1 #Down
            61   58  59 1
            62   19  24 1
            63   58  60 1
            64   61  62 2
            65   62  63 1
            66   63  64 2
            67   64  65 1
            68   65  66 2
            69   61  66 1
            70   65  67 1
            71   67  68 2
            72   68  69 1
            73   69  70 2
            74   66  70 1
            75   67  71 1
            76   71  72 1
            77   72  73 1
            78   73  74 2
            79   74  75 1
            80   75  76 2
            81   76  77 1
            82   72  77 2
            83   73  78 1
            84   78  79 2
            85   79  80 1
            86   80  81 2
            87   74  81 1
            88   69  82 1
            89   82  83 2
            90   82  84 1
            91   76  85 1
            92   85  86 2
            93   85  87 1
            94   68  88 1
            95   77  89 1
BRACKET     1     8.6100  -35.1400    8.6100  -10.0100
            1    25.6200  -10.0100   25.6200  -35.1400
            1  x
 ORIGINAL  1    1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16
            1   17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32
            1   33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48
            1   49  50  51  52  53  54  55  56  57  58  59  60
 REPEAT    1

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