KEGG   DRUG: SulconazoleHelp
Entry
D08535                      Drug                                   

Name
Sulconazole (INN)
Formula
C18H15Cl3N2S
Exact mass
396.0022
Mol weight
397.7491
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antifungal
 DG01883  Imidazole antifungal
Cyp inhibitor
 DG01643  CYP2C9 inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Imidazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
Steroid biosynthesis
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Drug interaction
Structure map
Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC09 Sulconazole
      D08535  Sulconazole (INN)
USP drug classification [BR:br08302]
 Antifungals
  Sulconazole
   D08535  Sulconazole (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Sulconazole
    D08535  Sulconazole (INN)
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   sterol 14alpha-demethylase inhibitor
    Imidazoles
     Sulconazole
      D08535  Sulconazole (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C9
   Sulconazole
    D08535  Sulconazole (INN)
BRITE hierarchy
Other DBs
CAS: 
61318-90-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    19.3900  -14.4200
            2   C8x C    19.3900  -15.8200
            3   C8x C    20.6500  -16.5200
            4   C8y C    21.8400  -15.8200
            5   C8x C    21.8400  -14.4200
            6   C8x C    20.6500  -13.7200
            7   X   Cl   18.2000  -13.7200
            8   C1b C    23.1000  -16.5200
            9   S2a S    24.2900  -15.8200
            10  C1c C    25.4800  -16.5200
            11  C1b C    26.6700  -15.8200
            12  C8y C    25.4800  -17.9200
            13  N4y N    27.8600  -16.5200
            14  C8x C    28.2800  -17.8500
            15  C8y C    24.2200  -18.6200
            16  C8x C    24.2200  -20.0200
            17  C8y C    25.4100  -20.7200
            18  C8x C    26.6700  -20.0200
            19  C8x C    26.6700  -18.6200
            20  N5x N    29.6800  -17.8500
            21  C8x C    30.1000  -16.5200
            22  C8x C    28.9800  -15.6800
            23  X   Cl   23.0300  -17.9200
            24  X   Cl   25.4100  -22.1200
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   10  12 1
            13   11  13 1
            14   13  14 1
            15   12  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   12  19 1
            21   14  20 2
            22   20  21 1
            23   21  22 2
            24   13  22 1
            25   15  23 1
            26   17  24 1

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