KEGG   DRUG: D08552Help
Entry
D08552                      Drug                                   

Name
Sunitinib (INN)
Formula
C22H27FN4O2
Exact mass
398.2118
Mol weight
398.4738
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic [DS:H00021]
Remark
ATC code: 
Drug group: 
Comment
Indications: Gastrointestinal stromal tumor, Advanced renal cell carcinoma, Pancreatic neuroendocrine tumors
Target
CSF1 inhibitor [HSA:1435] [KO:K05453];
FLT3 inhibitor [HSA:2322] [KO:K05092];
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
RET inhibitor [HSA:5979] [KO:K05126];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE04 Sunitinib
      D08552  Sunitinib (INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Sunitinib
    D08552  Sunitinib (INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Sunitinib
      D08552  Sunitinib (INN)
    PDGFRB tyrosine kinase
     Sunitinib
      D08552  Sunitinib (INN)
    c-KIT tyrosine kinase
     Sunitinib
      D08552  Sunitinib (INN)
    Fms-related tyrosine kinase 3
     Sunitinib
      D08552  Sunitinib (INN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Sunitinib
      D08552  Sunitinib (INN)
    VEGFR2 tyrosine kinase
     Sunitinib
      D08552  Sunitinib (INN)
    VEGFR3 tyrosine kinase
     Sunitinib
      D08552  Sunitinib (INN)
   RTK class XIV (RET receptor family)
    RET
     Sunitinib
      D08552  Sunitinib (INN)
 Cytokines
  PDGF family
   CSF1
    Sunitinib
     D08552  Sunitinib (INN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Receptor tyrosine kinase inhibitor
   Sunitinib
    D08552  Sunitinib (INN)
BRITE hierarchy
Other DBs
CAS: 
557795-19-4
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8x C    18.1300  -13.6500
            2   C8x C    16.9400  -14.3500
            3   C8y C    16.9400  -15.7500
            4   C8x C    18.1300  -16.4500
            5   C8y C    19.3200  -15.7500
            6   C8y C    19.3200  -14.3500
            7   C2y C    20.7200  -16.1700
            8   C5x C    21.4900  -15.0500
            9   N1x N    20.7200  -13.9300
            10  X   F    15.7500  -16.4500
            11  O5x O    22.8900  -15.0500
            12  C2b C    20.7200  -17.5700
            13  C8y C    21.9100  -18.2700
            14  C8y C    21.9100  -19.6700
            15  C8y C    23.2400  -20.0900
            16  C8y C    24.0100  -18.9700
            17  N4x N    23.2400  -17.8500
            18  C1a C    20.7200  -20.5100
            19  C1a C    25.4800  -18.9700
            20  C5a C    23.2400  -21.5600
            21  O5a O    22.0500  -22.2600
            22  N1b N    24.5000  -22.2600
            23  C1b C    25.6900  -21.5600
            24  C1b C    26.8800  -22.2600
            25  N1c N    28.0700  -21.5600
            26  C1b C    29.2600  -22.2600
            27  C1a C    30.4500  -21.5600
            28  C1b C    28.0700  -20.0900
            29  C1a C    29.2600  -19.4600
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12    8  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   14  18 1
            21   16  19 1
            22   15  20 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   25  28 1
            31   28  29 1

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