| Entry |
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| Name |
Tacrine (INN);
Tacrinal (TN)
|
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| Formula |
C13H14N2
|
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| Exact mass |
198.1157
|
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| Mol weight |
198.2637
|
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| Structure |
     |
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| Activity |
Antidote, curare antagonist;
Parasympathomimetic, cholinesterase inhibitor
|
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| Remark |
|
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| Target |
acetylcholinesterase (AChE) inhibitor [HSA: 43] [KO: K01049] |
|---|
| Pathway |
|
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
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| Interaction |
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| Structure map |
| Cholinergic and anticholinergic drugs |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06D ANTI-DEMENTIA DRUGS
N06DA Anticholinesterases
N06DA01 Tacrine
D08555 Tacrine (INN)
USP drug classification [BR:br08302]
Antidementia Agents
Cholinesterase Inhibitors
Tacrine
D08555 Tacrine (INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases
acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
Tacrine [ATC:N06DA01]
D08555 Tacrine (INN)
 |
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| Other DBs |
CAS: 321-64-2 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 15
1 C8y C 22.9600 -19.3200
2 C8y C 22.9600 -17.9200
3 N5x N 24.1500 -20.0200
4 C8x C 21.7000 -20.0200
5 C8y C 24.1500 -17.2200
6 C8x C 21.7000 -17.2200
7 C8y C 25.3400 -19.3200
8 C8x C 20.5100 -19.3200
9 C8y C 25.3400 -17.9200
10 N1a N 24.1500 -15.8200
11 C8x C 20.5100 -17.9200
12 C1x C 26.6000 -20.0200
13 C1x C 26.6000 -17.1500
14 C1x C 27.7900 -19.3200
15 C1x C 27.7900 -17.8500
BOND 17
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 5 9 2
9 5 10 1
10 6 11 2
11 7 12 1
12 9 13 1
13 12 14 1
14 13 15 1
15 7 9 1
16 8 11 1
17 14 15 1
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