KEGG   DRUG: TacrineHelp
Entry
D08555                      Drug                                   

Name
Tacrine (INN);
Tacrinal (TN)
Formula
C13H14N2
Exact mass
198.1157
Mol weight
198.2637
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antidote, Curare antagonist, Parasympathomimetic, Acetylcholinesterase inhibitor
Target
acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA01 Tacrine
      D08555  Tacrine (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Tacrine
     D08555  Tacrine (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Tacrine
    D08555  Tacrine (INN)
BRITE hierarchy
Other DBs
CAS: 
321-64-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   C8y C    22.9600  -19.3200
            2   C8y C    22.9600  -17.9200
            3   N5x N    24.1500  -20.0200
            4   C8x C    21.7000  -20.0200
            5   C8y C    24.1500  -17.2200
            6   C8x C    21.7000  -17.2200
            7   C8y C    25.3400  -19.3200
            8   C8x C    20.5100  -19.3200
            9   C8y C    25.3400  -17.9200
            10  N1a N    24.1500  -15.8200
            11  C8x C    20.5100  -17.9200
            12  C1x C    26.6000  -20.0200
            13  C1x C    26.6000  -17.1500
            14  C1x C    27.7900  -19.3200
            15  C1x C    27.7900  -17.8500
BOND        17
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   13  15 1
            15    7   9 1
            16    8  11 1
            17   14  15 1

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