KEGG   DRUG: D08555Help
Entry
D08555                      Drug                                   

Name
Tacrine (INN);
Tacrinal (TN)
Formula
C13H14N2
Exact mass
198.1157
Mol weight
198.2637
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidote, curare antagonist;
Parasympathomimetic, cholinesterase inhibitor
Remark
Same as: 
ATC code: 
Drug group: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA01 Tacrine
      D08555  Tacrine (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Tacrine
     D08555  Tacrine (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Tacrine
    D08555  Tacrine (INN)
BRITE hierarchy
Other DBs
CAS: 
321-64-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   C8y C    22.9600  -19.3200
            2   C8y C    22.9600  -17.9200
            3   N5x N    24.1500  -20.0200
            4   C8x C    21.7000  -20.0200
            5   C8y C    24.1500  -17.2200
            6   C8x C    21.7000  -17.2200
            7   C8y C    25.3400  -19.3200
            8   C8x C    20.5100  -19.3200
            9   C8y C    25.3400  -17.9200
            10  N1a N    24.1500  -15.8200
            11  C8x C    20.5100  -17.9200
            12  C1x C    26.6000  -20.0200
            13  C1x C    26.6000  -17.1500
            14  C1x C    27.7900  -19.3200
            15  C1x C    27.7900  -17.8500
BOND        17
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   13  15 1
            15    7   9 1
            16    8  11 1
            17   14  15 1

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