KEGG   DRUG: D08559Help
Entry
D08559                      Drug                                   

Name
Tamoxifen (INN);
Tamoxifen (TN);
Tamoplex (TN)
Formula
C26H29NO
Exact mass
371.2249
Mol weight
371.5146
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiestrogen [DS:H00031]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Selective estrogen receptor modulator (SERM)
Prodrug, active substance: Endoxifen [CPD:C16547])
Indication: Metastatic breast cancer
Use Tamoxifen to Patients who have factor V leiden mutation or prothrombin mutation is at risk of increase deep venous thrombosis (DVT).
Target
estrogen receptor 1 agonist/antagonist [HSA:2099] [KO:K08550];
estrogen receptor 2 agonist/antagonist [HSA:2100] [KO:K08551]
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2C9 [HSA:1559]
Interaction
Genomic biomarker: ESR [HSA:2099 2100], PGR [HSA:5241], F5 [HSA:2153], F2 [HSA:2147]
Transporter inhibition: ABCC2 [HSA:1244]
Drug interaction
Structure map
Antineoplastics - hormones
Progesterone, androgen and estrogen receptor agonists/antagonists
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02B HORMONE ANTAGONISTS AND RELATED AGENTS
    L02BA Anti-estrogens
     L02BA01 Tamoxifen
      D08559  Tamoxifen (INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Antiestrogens/Modifiers
   Tamoxifen
    D08559  Tamoxifen (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   Estrogen receptor
    estrogen receptor 1
     Tamoxifen
      D08559  Tamoxifen (INN)
    estrogen receptor 2
     Tamoxifen
      D08559  Tamoxifen (INN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Estrogen antagonist
   Tamoxifen
    D08559  Tamoxifen (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Tamoxifen
    D08559  Tamoxifen (INN)
  CYP2C9
   Tamoxifen
    D08559  Tamoxifen (INN)
  CYP2D6
   Tamoxifen
    D08559  Tamoxifen (INN)
  CYP3A4
   Tamoxifen
    D08559  Tamoxifen (INN)
BRITE hierarchy
Other DBs
CAS: 
10540-29-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8x C    24.7800  -19.3200
            2   C8y C    24.7800  -20.7200
            3   C8x C    23.5900  -21.4200
            4   C8x C    22.3300  -20.7200
            5   C8y C    22.3300  -19.3200
            6   C8x C    23.5900  -18.6200
            7   C8x C    19.8800  -20.7200
            8   C8y C    19.8800  -19.3200
            9   C2c C    21.1400  -18.6200
            10  C8x C    18.6900  -21.4200
            11  C8x C    17.5000  -20.7200
            12  C8x C    17.5000  -19.3200
            13  C8x C    18.6900  -18.6200
            14  C2c C    21.1400  -17.2200
            15  C1b C    19.8800  -16.5200
            16  C8y C    22.3300  -16.5200
            17  O2a O    25.9700  -21.4200
            18  C1b C    27.1600  -20.7200
            19  C1b C    28.3500  -21.4200
            20  C8x C    22.3300  -15.1200
            21  C8x C    23.5200  -14.4200
            22  C8x C    24.7800  -15.1200
            23  C8x C    24.7800  -16.5200
            24  C8x C    23.5200  -17.2200
            25  N1c N    29.5400  -20.7200
            26  C1a C    30.8000  -21.4200
            27  C1a C    29.5400  -19.3200
            28  C1a C    18.6900  -17.2200
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 2
            16   14  15 1
            17   14  16 1
            18    2  17 1
            19   17  18 1
            20   18  19 1
            21   16  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   16  24 1
            27   19  25 1
            28   25  26 1
            29   25  27 1
            30   15  28 1

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