KEGG   DRUG: D08560Help
Entry
D08560                      Drug                                   

Name
Tamsulosin (INN);
Flomax (TN);
Tamsulon (TN)
Formula
C20H28N2O5S
Exact mass
408.1719
Mol weight
408.5117
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Drug affecting the renal function and the urinary tract;
alfa-Adrenergic blocking
Remark
Same as: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor (especially alpha-1A) antagonist [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA02 Tamsulosin
      D08560  Tamsulosin (INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Tamsulosin
    D08560  Tamsulosin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Tamsulosin
      D08560  Tamsulosin (INN)
BRITE hierarchy
Other DBs
CAS: 
106133-20-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    21.2100  -18.9700
            2   C1b C    22.4000  -19.6700
            3   C1c C    23.5900  -18.9700
            4   N1b N    24.7800  -19.6700
            5   C1b C    26.0400  -18.9700
            6   C1b C    27.2300  -19.6700
            7   O2a O    28.4200  -18.9700
            8   C8y C    29.6800  -19.6700
            9   C8x C    30.8700  -18.9700
            10  C8x C    21.2100  -17.5700
            11  C8y C    19.9500  -16.8700
            12  C8y C    18.7600  -17.5700
            13  C8x C    18.7600  -18.9700
            14  C8x C    19.9500  -19.6700
            15  C1a C    23.5900  -17.5700
            16  C8y C    29.6800  -21.0700
            17  C8x C    30.8700  -21.7700
            18  C8x C    32.0600  -21.0700
            19  C8x C    32.0600  -19.6700
            20  O2a O    28.4200  -21.7700
            21  O2a O    17.5000  -16.8700
            22  C1a C    16.3100  -17.5700
            23  S4a S    19.9500  -15.4700
            24  O3c O    18.5500  -15.4700
            25  N1a N    19.9500  -14.0700
            26  O3c O    21.3500  -15.4700
            27  C1b C    27.2300  -21.0000
            28  C1a C    25.9700  -21.7000
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     1  10 2
            10   10  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14    1  14 1
            15    3  15 1 #Up
            16    8  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19   9 2
            21   16  20 1
            22   12  21 1
            23   21  22 1
            24   11  23 1
            25   23  24 2
            26   23  25 1
            27   23  26 2
            28   20  27 1
            29   27  28 1

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