| Entry |
|
|---|
| Name |
Tetrabenazine (JAN/INN);
Nitoman (TN);
Xenazine (TN)
|
|---|
| Product |
|
|---|
| Formula |
C19H27NO3
|
|---|
| Exact mass |
317.1991
|
|---|
| Mol weight |
317.4226
|
|---|
| Structure |
     |
|---|
| Activity |
|
|---|
| Remark |
Same as: Therapeutic category: ATC code: |
|---|
| Comment |
Indication: Huntington's disease
|
|---|
| Target |
Vesicular monoamine transporter 2 (VMAT2) inhibitor [HSA: 6571] [KO: K08155] |
|---|
| Pathway |
|
|---|
| Interaction |
Genomic biomarker: CYP2D6 [HSA: 1565]
 |
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
119 Miscellaneous
1190 Miscellaneous
D08575 Tetrabenazine (JAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07X OTHER NERVOUS SYSTEM DRUGS
N07XX Other nervous system drugs
N07XX06 Tetrabenazine
D08575 Tetrabenazine (JAN/INN)
USP drug classification [BR:br08302]
Central Nervous System Agents
Central Nervous System, Other
Tetrabenazine
D08575 Tetrabenazine (JAN/INN)
Target-based classification of drugs [BR:br08310]
Transporters
Major facilitator superfamily
Vesicular monoamine transporter 2 (VMAT2) [HSA:6571] [KO:K08155]
Tetrabenazine [ATC:N07XX06]
D08575 Tetrabenazine (INN)
 |
|---|
| Other DBs |
CAS: 58-46-8 PubChem: DrugBank: LigandBox: NIKKAJI: |
|---|
| KCF data |
ATOM 23
1 C1x C 24.2200 -16.8700
2 C1y C 24.2200 -18.2700
3 N1y N 25.4100 -18.9700
4 C1x C 26.6700 -18.2700
5 C1y C 26.6700 -16.8700
6 C5x C 25.4100 -16.1700
7 C8y C 23.0300 -18.9700
8 C8y C 23.0300 -20.3700
9 C1x C 24.2200 -21.0700
10 C1x C 25.4100 -20.3700
11 C8y C 20.5800 -18.9700
12 C8y C 20.5800 -20.3700
13 C8x C 21.7700 -21.0700
14 C8x C 21.7700 -18.2700
15 O5x O 25.4100 -14.7700
16 C1b C 27.8600 -16.1700
17 C1c C 29.0500 -16.8700
18 C1a C 30.2400 -16.1700
19 C1a C 29.0500 -18.2700
20 O2a O 19.3900 -18.2700
21 O2a O 19.3900 -21.0700
22 C1a C 18.1300 -18.9700
23 C1a C 18.1300 -20.3700
BOND 25
1 5 6 1
2 6 1 1
3 11 12 2
4 12 13 1
5 13 8 2
6 7 14 2
7 14 11 1
8 1 2 1
9 6 15 2
10 2 3 1
11 5 16 1
12 3 4 1
13 16 17 1
14 7 8 1
15 17 18 1
16 8 9 1
17 17 19 1
18 9 10 1
19 11 20 1
20 10 3 1
21 12 21 1
22 2 7 1
23 20 22 1
24 4 5 1
25 21 23 1
|
|---|
