KEGG   DRUG: D08587Help
Entry
D08587                      Drug                                   

Name
Thonzylamine (INN);
Tonamil (TN)
Formula
C16H22N4O
Exact mass
286.1794
Mol weight
286.3721
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist;
Antihistaminic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA01 Thonzylamine
      D08587  Thonzylamine (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC06 Thonzylamine
      D08587  Thonzylamine (INN)
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AC Substituted ethylene diamines
     R06AC06 Thonzylamine
      D08587  Thonzylamine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 2
  Inorganic and organic chemicals
   Thonzylamine
    D08587  Thonzylamine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Thonzylamine
      D08587  Thonzylamine (INN)
BRITE hierarchy
Other DBs
CAS: 
91-85-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   N5x N    19.7400  -22.4000
            2   C8x C    19.7400  -23.8000
            3   C8x C    20.9524  -24.5000
            4   C8x C    22.1649  -23.8000
            5   N5x N    22.1649  -22.4000
            6   C8y C    20.9524  -21.7000
            7   N1c N    20.9524  -20.3002
            8   C1b C    19.7232  -19.5903
            9   C1b C    22.1480  -19.6098
            10  C8y C    18.5192  -20.2854
            11  C8x C    17.3363  -19.6023
            12  C8x C    16.1238  -20.3022
            13  C8y C    16.1237  -21.7022
            14  C8x C    17.3067  -22.3853
            15  C8x C    18.5191  -21.6854
            16  O2a O    14.8945  -22.4119
            17  C1a C    13.6886  -21.7157
            18  C1b C    23.3352  -20.2952
            19  N1c N    24.5266  -19.6072
            20  C1a C    25.7159  -20.2939
            21  C1a C    24.5267  -18.2003
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     7   9 1
            10    8  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   10  15 1
            17   13  16 1
            18   16  17 1
            19    9  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1

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