KEGG   DRUG: D08607Help
Entry
D08607                      Drug                                   

Name
Tirofiban (INN);
Agrastat (TN)
Formula
C22H36N2O5S
Exact mass
440.2345
Mol weight
440.5966
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticoagulant, platelet aggregation inhibitor
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Indication: Acute coronary syndrome
Target
glycoprotein alphaIIb/beta3 (GPIIb/IIIa) receptor antagonist [HSA:3674 3690] [KO:K06476 K06493]
  Pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction  
 
Interaction
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC17 Tirofiban
      D08607  Tirofiban (INN)
Target-based classification of drugs [BR:br08310]
 Others
  Cell adhesion molecules (CAMs)
   glycoprotein alpha IIb/beta3 (GPIIb/IIIa) receptor
    Tirofiban
     D08607  Tirofiban (INN)
BRITE hierarchy
Other DBs
CAS: 
144494-65-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        30
            1   C8y C    16.8671  -15.7324
            2   C1b C    15.6736  -15.0303
            3   C8x C    16.8673  -17.1366
            4   C8x C    18.0607  -15.0303
            5   C1c C    14.4098  -15.7324
            6   C8x C    18.0607  -17.8387
            7   C8x C    19.2543  -15.7324
            8   N1b N    14.4098  -17.1366
            9   C6a C    13.2162  -15.0303
            10  C8y C    19.2543  -17.1366
            11  S4a S    13.2864  -17.9089
            12  O6a O    12.0227  -15.7324
            13  O6a O    13.2162  -13.6262
            14  O2a O    20.5180  -17.8387
            15  C1b C    12.0227  -17.1366
            16  O3c O    14.4800  -18.7515
            17  O3c O    12.1631  -18.7515
            18  C1b C    21.7116  -17.1366
            19  C1b C    10.8291  -17.8387
            20  C1b C    22.9052  -17.8387
            21  C1b C     9.5653  -17.1366
            22  C1b C    24.0987  -17.1366
            23  C1a C     8.3717  -17.8387
            24  C1b C    25.3625  -17.8387
            25  C1y C    26.5561  -17.1366
            26  C1x C    27.7496  -17.8387
            27  C1x C    26.5561  -15.7324
            28  C1x C    28.9432  -17.1366
            29  C1x C    27.7496  -15.0303
            30  N1x N    28.9432  -15.7324
BOND        31
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1 #Down
            8     5   9 1
            9     6  10 2
            10    8  11 1
            11    9  12 1
            12    9  13 2
            13   10  14 1
            14   11  15 1
            15   11  16 2
            16   11  17 2
            17   14  18 1
            18   15  19 1
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22   21  23 1
            23   22  24 1
            24   24  25 1
            25   25  26 1
            26   25  27 1
            27   26  28 1
            28   27  29 1
            29   28  30 1
            30    7  10 1
            31   29  30 1

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