KEGG   DRUG: TolazolineHelp
Entry
D08614                      Drug                                   

Name
Tolazoline (INN);
Tolazine [veterinary] (TN)
Formula
C10H12N2
Exact mass
160.1
Mol weight
160.2157
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Remark
Same as: C07147
ATC code: C04AB02 M02AX02
Chemical structure group: DG00281
Efficacy
Vasodilator (peripheral), alpha-Adrenergic receptor antagonist
Comment
Imidazoline derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C04 PERIPHERAL VASODILATORS
   C04A PERIPHERAL VASODILATORS
    C04AB Imidazoline derivatives
     C04AB02 Tolazoline
      D08614  Tolazoline (INN)
 M MUSCULO-SKELETAL SYSTEM
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AX Other topical products for joint and muscular pain
     M02AX02 Tolazoline
      D08614  Tolazoline (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D08614  Tolazoline (INN)
    ADRA2
     D08614  Tolazoline (INN)
BRITE hierarchy
Other DBs
CAS: 59-98-3
PubChem: 96025298
ChEBI: 28502
ChEMBL: CHEMBL770
DrugBank: DB00797
LigandBox: D08614
NIKKAJI: J4.796A
KCF data Show

ATOM        12
            1   C8x C    21.1400  -17.9900
            2   C8x C    21.1400  -19.3900
            3   C8x C    19.9500  -20.0900
            4   C8x C    18.6900  -19.3900
            5   C8x C    18.6900  -17.9900
            6   C8y C    19.9500  -17.2900
            7   C1b C    19.9500  -15.8900
            8   C2y C    21.1400  -15.1900
            9   N2x N    21.1400  -13.7900
            10  C1x C    22.4700  -13.3700
            11  C1x C    23.3100  -14.4900
            12  N1x N    22.4700  -15.6100
BOND        13
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    8  12 1

» Japanese version   » Back

DBGET integrated database retrieval system