KEGG   DRUG: D08614Help
Entry
D08614                      Drug                                   

Name
Tolazoline (INN);
Tolazine [veterinary] (TN)
Formula
C10H12N2
Exact mass
160.1
Mol weight
160.2157
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator, peripheric;
alfa-Adrenergic blocking
Remark
Same as: 
ATC code: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C04 PERIPHERAL VASODILATORS
   C04A PERIPHERAL VASODILATORS
    C04AB Imidazoline derivatives
     C04AB02 Tolazoline
      D08614  Tolazoline (INN)
 M MUSCULO-SKELETAL SYSTEM
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AX Other topical products for joint and muscular pain
     M02AX02 Tolazoline
      D08614  Tolazoline (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Tolazoline [ATC:C04AB02 M02AX02]
      D08614  Tolazoline (INN)
    alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
     Tolazoline [ATC:C04AB02 M02AX02]
      D08614  Tolazoline (INN)
BRITE hierarchy
Other DBs
CAS: 
59-98-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C8x C    21.1400  -17.9900
            2   C8x C    21.1400  -19.3900
            3   C8x C    19.9500  -20.0900
            4   C8x C    18.6900  -19.3900
            5   C8x C    18.6900  -17.9900
            6   C8y C    19.9500  -17.2900
            7   C1b C    19.9500  -15.8900
            8   C2y C    21.1400  -15.1900
            9   N2x N    21.1400  -13.7900
            10  C1x C    22.4700  -13.3700
            11  C1x C    23.3100  -14.4900
            12  N1x N    22.4700  -15.6100
BOND        13
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    8  12 1

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