KEGG   DRUG: D08626Help
Entry
D08626                      Drug                                   

Name
Trazodone (INN);
Trittico (TN)
Formula
C19H22ClN5O
Exact mass
371.1513
Mol weight
371.8639
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer;
Antidepressant
Remark
Same as: 
ATC code: 
Drug group: 
Comment
triazolopyridines
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX05 Trazodone
      D08626  Trazodone (INN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Trazodone
    D08626  Trazodone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT2A-receptor
     Trazodone
      D08626  Trazodone (INN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Trazodone
      D08626  Trazodone (INN)
     Trazodone
      D08626  Trazodone (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Trazodone
    D08626  Trazodone (INN)
  CYP3A4
   Trazodone
    D08626  Trazodone (INN)
  CYP3A5
   Trazodone
    D08626  Trazodone (INN)
  CYP3A7
   Trazodone
    D08626  Trazodone (INN)
BRITE hierarchy
Other DBs
CAS: 
19794-93-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   N4y N    17.8500  -18.4800
            2   C1b C    19.0400  -19.1800
            3   C1b C    20.2300  -18.5500
            4   C1b C    21.4200  -19.2500
            5   N1y N    22.6800  -18.5500
            6   C1x C    22.6800  -17.1500
            7   C1x C    23.8700  -19.2500
            8   C1x C    23.8700  -16.3800
            9   C1x C    25.1300  -18.5500
            10  N1y N    25.1300  -17.1500
            11  C8y C    26.3200  -16.3800
            12  C8x C    26.3200  -14.9800
            13  C8x C    27.5100  -17.1500
            14  C8y C    27.5100  -14.2800
            15  C8x C    28.7700  -16.3800
            16  C8x C    28.7700  -14.9800
            17  X   Cl   27.5100  -12.8800
            18  N5x N    17.5000  -17.0800
            19  C8y C    16.1000  -17.0800
            20  N4y N    15.6100  -18.4100
            21  C8y C    16.7300  -19.2500
            22  O5x O    16.7300  -20.5800
            23  C8x C    15.1200  -16.0300
            24  C8x C    13.7900  -16.3100
            25  C8x C    13.3000  -17.6400
            26  C8x C    14.2800  -18.6900
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     5   7 1
            7     6   8 1
            8     7   9 1
            9     8  10 1
            10   10  11 1
            11   11  12 1
            12   11  13 2
            13   12  14 2
            14   13  15 1
            15   14  16 1
            16   14  17 1
            17    9  10 1
            18   15  16 2
            19    1  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 1
            23    1  21 1
            24   21  22 2
            25   19  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   20  26 1

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