| Entry |
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| Name |
Trazodone (INN);
Trittico (TN)
|
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| Formula |
C19H22ClN5O
|
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| Exact mass |
371.1513
|
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| Mol weight |
371.8639
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| Structure |
     |
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| Activity |
Tranquilizer;
Antidepressant
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| Remark |
|
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| Comment |
triazolopyridines
|
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| Target |
serotonin transporter inhibitor [HSA: 6532] [KO: K05037]; 5-HT2A-receptor antagonist [HSA: 3356] [KO: K04157] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
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| Interaction |
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| Structure map |
| Antidepressants | | Neurotransmitter transporter inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX05 Trazodone
D08626 Trazodone (INN)
USP drug classification [BR:br08302]
Antidepressants
Antidepressants, Other
Trazodone
D08626 Trazodone (INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
5-HT2A-receptor [HSA:3356] [KO:K04157]
Trazodone [ATC:N06AX05]
D08626 Trazodone (INN)
Transporters
Solute carrier family
SLC6
SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
Trazodone [ATC:N06AX05]
D08626 Trazodone (INN)
 |
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| Other DBs |
CAS: 19794-93-5 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 26
1 N4y N 28.9800 -17.1500
2 C8y C 29.6800 -15.9600
3 C8y C 27.5800 -16.8700
4 C8x C 29.6800 -18.3400
5 N5x N 28.7700 -14.9100
6 C8x C 31.0800 -15.9600
7 N4y N 27.4400 -15.4700
8 O5x O 26.6000 -17.7800
9 C8x C 31.0800 -18.3400
10 C8x C 31.7800 -17.1500
11 C1b C 26.2500 -14.7700
12 C1b C 25.0600 -15.4700
13 C1b C 23.8000 -14.7700
14 N1y N 22.6100 -15.4700
15 C1x C 22.6100 -16.8700
16 C1x C 21.4200 -14.7700
17 C1x C 21.4200 -17.5700
18 C1x C 20.1600 -15.4700
19 N1y N 20.1600 -16.8700
20 C8y C 18.9700 -17.5700
21 C8x C 18.9700 -18.9700
22 C8x C 17.7800 -16.8700
23 C8y C 17.7800 -19.6700
24 C8x C 16.5200 -17.5700
25 C8x C 16.5200 -18.9700
26 X Cl 17.7800 -21.0700
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 2
9 6 10 2
10 7 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 14 15 1
15 14 16 1
16 15 17 1
17 16 18 1
18 17 19 1
19 19 20 1
20 20 21 1
21 20 22 2
22 21 23 2
23 22 24 1
24 23 25 1
25 23 26 1
26 5 7 1
27 9 10 1
28 18 19 1
29 24 25 2
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