KEGG   DRUG: D08626Help
Entry
D08626                      Drug                                   

Name
Trazodone (INN);
Trittico (TN)
Formula
C19H22ClN5O
Exact mass
371.1513
Mol weight
371.8639
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer;
Antidepressant
Remark
Same as: 
ATC code: 
Comment
triazolopyridines
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX05 Trazodone
      D08626  Trazodone (INN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Trazodone
    D08626  Trazodone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT2A-receptor [HSA:3356] [KO:K04157]
     Trazodone [ATC:N06AX05]
      D08626  Trazodone (INN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Trazodone [ATC:N06AX05]
      D08626  Trazodone (INN)
BRITE hierarchy
Other DBs
CAS: 
19794-93-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   N4y N    28.9800  -17.1500
            2   C8y C    29.6800  -15.9600
            3   C8y C    27.5800  -16.8700
            4   C8x C    29.6800  -18.3400
            5   N5x N    28.7700  -14.9100
            6   C8x C    31.0800  -15.9600
            7   N4y N    27.4400  -15.4700
            8   O5x O    26.6000  -17.7800
            9   C8x C    31.0800  -18.3400
            10  C8x C    31.7800  -17.1500
            11  C1b C    26.2500  -14.7700
            12  C1b C    25.0600  -15.4700
            13  C1b C    23.8000  -14.7700
            14  N1y N    22.6100  -15.4700
            15  C1x C    22.6100  -16.8700
            16  C1x C    21.4200  -14.7700
            17  C1x C    21.4200  -17.5700
            18  C1x C    20.1600  -15.4700
            19  N1y N    20.1600  -16.8700
            20  C8y C    18.9700  -17.5700
            21  C8x C    18.9700  -18.9700
            22  C8x C    17.7800  -16.8700
            23  C8y C    17.7800  -19.6700
            24  C8x C    16.5200  -17.5700
            25  C8x C    16.5200  -18.9700
            26  X   Cl   17.7800  -21.0700
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 2
            9     6  10 2
            10    7  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 2
            23   22  24 1
            24   23  25 1
            25   23  26 1
            26    5   7 1
            27    9  10 1
            28   18  19 1
            29   24  25 2

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