KEGG   DRUG: D08637Help
Entry
D08637                      Drug                                   

Name
Trifluperidol hydrochloride;
Triperidol (TN)
Formula
C22H24F4NO2. Cl
Exact mass
445.1432
Mol weight
445.8781
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic
Remark
ATC code: 
Drug group: 
Target
dopamine D2 receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Butyrophenones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD02 Trifluperidol
      D08637  Trifluperidol hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Trifluperidol
      D08637  Trifluperidol hydrochloride
BRITE hierarchy
Other DBs
CAS: 
2062-77-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C8x C    18.3966  -19.7370
            2   C8y C    18.3966  -21.1419
            3   C8x C    19.5907  -21.8443
            4   C8x C    20.7848  -21.1419
            5   C8y C    20.7848  -19.7370
            6   C8x C    19.5907  -19.0346
            7   C5a C    22.0492  -19.0346
            8   C1b C    23.2433  -19.7370
            9   C1b C    24.4375  -19.0346
            10  C1b C    25.7018  -19.7370
            11  N2y N    26.8960  -19.0346 #+
            12  C1x C    28.1603  -19.8073
            13  C1x C    29.3544  -19.1048
            14  C1z C    29.3544  -17.7000
            15  C1x C    28.0901  -16.9975
            16  C1x C    26.8960  -17.7000
            17  C8y C    30.6188  -16.9273
            18  C8x C    31.8129  -17.6297
            19  C8y C    33.0071  -16.9273
            20  C8x C    33.0071  -15.5224
            21  C8x C    31.8129  -14.8903
            22  C8x C    30.6188  -15.5927
            23  C1d C    34.2012  -17.7000
            24  X   F    35.4656  -18.4024
            25  X   F    34.9036  -16.4356
            26  X   F    33.5690  -18.8941
            27  O1a O    30.5486  -18.4024
            28  O5a O    22.0492  -17.7000
            29  X   F    17.1322  -21.8443
            30  X   Cl   26.9127  -21.7736 #-
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   11  16 1
            18   14  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   19  23 1
            26   23  24 1
            27   23  25 1
            28   23  26 1
            29   14  27 1
            30    7  28 2
            31    2  29 1

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