KEGG   DRUG: D08638Help
Entry
D08638                      Drug                                   

Name
Trihexyphenidyl (INN);
Apo-trihex (TN)
Formula
C20H31NO
Exact mass
301.2406
Mol weight
301.4662
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiparkinsonian, central anticholinergic
Remark
Same as: 
ATC code: 
Drug group: 
Comment
centrally active anticholinergic drugs
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA01 Trihexyphenidyl
      D08638  Trihexyphenidyl (INN)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Anticholinergics
   Trihexyphenidyl
    D08638  Trihexyphenidyl (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Trihexyphenidyl
      D08638  Trihexyphenidyl (INN)
BRITE hierarchy
Other DBs
CAS: 
144-11-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8x C    22.2262  -19.7138
            2   C8x C    23.4847  -19.0147
            3   C8x C    23.4846  -17.6164
            4   C8x C    22.2262  -16.8473
            5   C8y C    21.0376  -17.5465
            6   C8x C    21.0376  -19.0147
            7   C1x C    20.9676  -14.8198
            8   C1y C    19.7791  -15.5190
            9   C1d C    19.7792  -16.8473
            10  C1x C    20.9676  -13.3516
            11  C1x C    19.7092  -12.6525
            12  C1x C    18.5206  -13.3516
            13  C1x C    18.5206  -14.7499
            14  C1b C    18.5906  -17.5465
            15  C1b C    17.4021  -16.9173
            16  N1y N    16.1436  -17.6164
            17  C1x C    14.9550  -16.9173
            18  C1x C    13.7665  -17.6164
            19  C1x C    13.7665  -19.0147
            20  C1x C    14.9550  -19.6439
            21  C1x C    16.1436  -18.9448
            22  O1a O    21.0376  -16.1482
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   16  21 1
            24    9  22 1

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