Entry |
|
Name |
Trimethoprim lactate; Wellcoprim (TN) |
Formula |
C14H18N4O3. C3H6O3
|
Exact mass |
380.1696
|
Mol weight |
380.3957
|
Structure |
|
Simcomp |
|
Class |
Antibacterial
DG01581 Trimethoprim antibacterial
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
|
Remark |
Product (DG00595): | D00145<US> |
Product (mixture): | D11086<US> |
|
Efficacy |
Antibacterial, Folic acid biosynthesis inhibitor |
Target |
dihydrofolate reductase [KO: K13938] |
Pathway |
|
Interaction |
CYP inhibition: CYP2C8 [HSA: 1558]
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01E SULFONAMIDES AND TRIMETHOPRIM
J01EA Trimethoprim and derivatives
J01EA01 Trimethoprim
D08644 Trimethoprim lactate
Drug groups [BR:br08330]
Antibacterial
DG01581 Trimethoprim antibacterial
DG00595 Trimethoprim
D08644 Trimethoprim lactate
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00595 Trimethoprim
D08644 Trimethoprim lactate
Antimicrobials [BR:br08307]
Antibacterials
Folic acid biosynthesis inhibitor
Trimethoprim
D08644 Trimethoprim lactate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08644
Drug groups [BR:br08330]
Antibacterial
DG01581 Trimethoprim antibacterial
DG00595 Trimethoprim
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00595 Trimethoprim
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Folic acid biosynthesis inhibitor
Trimethoprim
DG00595 Trimethoprim
|
Other DBs |
|
KCF data |
ATOM 27
1 C8y C 20.0900 -18.9700
2 C1b C 21.2800 -19.6700
3 C8x C 18.9000 -19.6700
4 C8x C 20.0900 -17.5700
5 C8y C 22.4700 -18.9700
6 C8y C 17.6400 -18.9700
7 C8y C 18.9000 -16.8700
8 C8y C 23.7300 -19.6700
9 C8x C 22.4700 -17.5000
10 C8y C 17.6400 -17.5700
11 O2a O 16.4500 -19.6700
12 O2a O 18.9000 -15.4700
13 N5x N 24.9200 -18.9700
14 N1a N 23.7300 -21.0700
15 N5x N 23.7300 -16.8000
16 O2a O 16.4500 -16.9400
17 C1a C 15.2600 -18.9000
18 C1a C 20.0900 -14.7700
19 C8y C 24.9200 -17.5000
20 C1a C 16.4500 -15.4700
21 N1a N 26.1100 -16.8000
22 O1a O 30.8700 -17.7800
23 C1c C 32.0824 -18.4800
24 C6a C 33.2949 -17.7800
25 O6a O 34.5073 -18.4800
26 C1a C 32.0824 -19.8798
27 O6a O 33.2949 -16.3802
BOND 27
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 2
8 5 9 1
9 6 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 8 14 1
14 9 15 2
15 10 16 1
16 11 17 1
17 12 18 1
18 13 19 2
19 16 20 1
20 19 21 1
21 7 10 2
22 15 19 1
23 22 23 1
24 23 24 1
25 24 25 1
26 23 26 1
27 24 27 2
|