KEGG   DRUG: D08661Help
Entry
D08661                      Drug                                   

Name
Unoprostone (INN);
Rescula (TN)
Formula
C22H38O5
Exact mass
382.2719
Mol weight
382.5341
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Glaucoma treatment
Remark
ATC code: 
Drug group: 
Target
prostaglandin F receptor agonist [HSA:5737] [KO:K04262]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE02 Unoprostone
      D08661  Unoprostone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    prostaglandin F receptor
     Unoprostone
      D08661  Unoprostone (INN)
BRITE hierarchy
Other DBs
CAS: 
120373-36-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C1y C    18.9311  -21.5876
            2   C1y C    18.9311  -22.9898
            3   C1y C    17.6691  -21.1669
            4   C1b C    20.3335  -20.1151
            5   C1y C    17.6691  -23.4106
            6   C1b C    20.1231  -23.9715
            7   C1x C    16.8277  -22.2887
            8   O1a O    17.1783  -19.8347
            9   C2b C    21.5254  -20.7462
            10  O1a O    17.2484  -24.7427
            11  C1b C    21.3150  -23.3404
            12  C2b C    22.8576  -20.7462
            13  C5a C    22.5070  -23.9715
            14  C1b C    24.0495  -20.1151
            15  C1b C    23.6989  -23.3404
            16  O5a O    22.5070  -25.3737
            17  C1b C    25.2415  -20.7462
            18  C1b C    24.8909  -23.9715
            19  C1b C    26.4334  -20.0450
            20  C1b C    26.0828  -23.3404
            21  C6a C    27.5553  -20.7462
            22  C1b C    27.2047  -23.9715
            23  O6a O    28.8173  -20.0450
            24  O6a O    27.5554  -22.1485
            25  C1b C    28.3966  -23.3404
            26  C1b C    29.5886  -24.0416
            27  C1a C    30.8506  -23.3404
BOND        27
            1    15  18 1
            2    17  19 1
            3    18  20 1
            4    19  21 1
            5    20  22 1
            6    21  23 1
            7    21  24 2
            8    22  25 1
            9     5   7 1
            10    1   2 1
            11    1   3 1
            12    1   4 1 #Down
            13    2   5 1
            14    2   6 1 #Up
            15    3   7 1
            16    3   8 1 #Down
            17    4   9 1
            18    5  10 1 #Down
            19    6  11 1
            20    9  12 2
            21   11  13 1
            22   12  14 1
            23   13  15 1
            24   13  16 2
            25   25  26 1
            26   14  17 1
            27   26  27 1

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