KEGG   DRUG: D08675Help
Entry
D08675                      Drug                                   

Name
Vinblastine (INN);
Vinblastina (TN)
Formula
C46H58N4O9
Exact mass
810.4204
Mol weight
810.9741
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Catharanthus roseus [TAX:4058]
Activity
Antineoplastic, antimitotic [DS:H00007 H00014 H00021 H00022 H00028 H00030 H00041]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
vinca alkaloid
Target
beta-tubulin, tubulin polymerization inhibitor [HSA:10381 10382 10383 203068 347688 347733 56604 7280 81027 84617] [KO:K07375]
  Pathway
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243], ABCB4 [HSA:5244]
Interaction
Drug interaction
Structure map
Antineoplastics - agents from natural products
Immunosuppressive agents
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
    L01CA Vinca alkaloids and analogues
     L01CA01 Vinblastine
      D08675  Vinblastine (INN)
Target-based classification of drugs [BR:br08310]
 Others
  Cytoskeleton proteins
   beta-tubulin
    Vinblastine
     D08675  Vinblastine (INN)
Antineoplastics [BR:br08308]
 Natural products
  Mitotic inhibitor
   Vinblastine
    D08675  Vinblastine (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Vinblastine
    D08675  Vinblastine (INN)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Indole alkaloids
    D08675  Vinblastine (INN)
BRITE hierarchy
Other DBs
CAS: 
865-21-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        59
            1   C1z C    19.1800  -16.6600
            2   C8y C    18.0600  -15.8900
            3   C1x C    20.4400  -15.8900
            4   C7a C    18.8300  -17.9200
            5   C8y C    18.0600  -14.4900
            6   N4x N    16.9400  -16.5200
            7   C1y C    20.4400  -14.6300
            8   O7a O    17.3600  -18.4100
            9   O6a O    19.6700  -18.9700
            10  C8y C    15.7500  -14.4900
            11  C1x C    17.2900  -13.3700
            12  C8y C    15.7500  -15.8900
            13  C1x C    19.3200  -14.0000
            14  C1a C    16.5200  -19.8100
            15  C8x C    14.5600  -13.8600
            16  C1x C    18.0600  -12.3900
            17  C8x C    14.5600  -16.5200
            18  N1y N    19.3200  -12.7400
            19  C8x C    13.5100  -14.4900
            20  C8x C    13.5100  -15.8900
            21  C1x C    20.4400  -11.9700
            22  C1z C    21.5600  -12.6000
            23  C1x C    21.5600  -13.7900
            24  O1a O    22.8200  -11.9000
            25  C1b C    22.7500  -13.3000
            26  C1a C    22.7500  -14.7000
            27  C1z C    26.7400  -18.8300
            28  C1y C    27.8600  -18.1300
            29  C1y C    26.7400  -20.0900
            30  C1x C    25.9000  -17.7100
            31  C1z C    28.9800  -18.8300
            32  N1y N    27.8600  -16.8000
            33  C1z C    27.8600  -20.7900
            34  N1y N    25.6200  -20.7900
            35  C8y C    24.5000  -20.0900
            36  C1x C    26.5300  -16.8000
            37  C1y C    28.9800  -20.0900
            38  C2x C    30.1700  -18.1300
            39  C1b C    30.1000  -19.4600
            40  C1x C    28.9800  -16.1700
            41  C7a C    28.7700  -21.9100
            42  O1a O    27.3700  -22.6800
            43  C1a C    25.6200  -22.1200
            44  O7a O    32.3400  -21.4200
            45  C2x C    30.1700  -16.8000
            46  C1a C    31.2200  -18.8300
            47  O7a O    28.7700  -23.2400
            48  O6a O    30.1000  -21.4200
            49  C1a C    29.9600  -23.9400
            50  C1a C    34.7900  -21.4200
            51  C7a C    33.5300  -20.7200
            52  O6a O    33.5300  -19.3200
            53  C8y C    24.5000  -18.8300
            54  C8x C    23.3800  -18.2000
            55  C8x C    23.3800  -20.7900
            56  C8y C    22.2600  -18.8300
            57  C8y C    22.2600  -20.1600
            58  O2a O    21.1400  -20.7900
            59  C1a C    20.0200  -20.1600
BOND        67
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1 #Down
            13    7  23 1
            14    8  14 1
            15   10  15 1
            16   11  16 1
            17   12  17 1
            18   18  13 1 #Down
            19   15  19 2
            20   17  20 2
            21   18  21 1
            22   10  12 2
            23   16  18 1
            24   22  21 1
            25   19  20 1
            26   22  23 1
            27   22  24 1 #Up
            28   22  25 1 #Down
            29   25  26 1
            30   27  28 1
            31   27  29 1
            32   27  30 1 #Up
            33   28  31 1
            34   28  32 1
            35   29  33 1
            36   29  34 1
            37   30  36 1
            38   31  37 1
            39   31  38 1
            40   31  39 1 #Down
            41   32  40 1
            42   33  41 1 #Down
            43   33  42 1 #Up
            44   34  43 1
            45   37  44 1 #Up
            46   38  45 2
            47   39  46 1
            48   41  47 1
            49   32  36 1
            50   33  37 1
            51   34  35 1
            52   40  45 1
            53   41  48 2
            54   47  49 1
            55   50  51 1
            56   44  51 1
            57   51  52 2
            58   53  54 1
            59   35  55 1
            60   54  56 2
            61   55  57 2
            62   57  58 1
            63   58  59 1
            64   56  57 1
            65   53  27 1
            66   53  35 2
            67    1  56 1 #Down

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