KEGG   DRUG: D08679Help
Entry
D08679                      Drug                                   

Name
Vincristine (INN);
Tecnocris (TN)
Formula
C46H56N4O10
Exact mass
824.3996
Mol weight
824.9576
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Catharanthus roseus (Vinca rosea) [TAX:4058]
Activity
Antineoplastic, antimitotic
Remark
Same as: 
ATC code: 
Comment
Vinca alkaloid from Catharanthus roseus (Madagascar periwinkle)
Target
beta-tubulin, tubulin polymerization inhibitor [HSA:10381 10382 10383 203068 347688 347733 56604 7280 81027 84617] [KO:K07375]
  Pathway
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antineoplastics - agents from natural products
Immunosuppressive agents
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
    L01CA Vinca alkaloids and analogues
     L01CA02 Vincristine
      D08679  Vincristine (INN)
Target-based classification of drugs [BR:br08310]
 Others
  Cytoskeleton proteins
   beta-tubulin [HSA:10381 10382 10383 203068 347688 347733 56604 7280 81027 84617] [KO:K07375]
    Vincristine [ATC:L01CA02]
     D08679  Vincristine (INN)
Antineoplastics [BR:br08308]
 Natural products
  Mitotic inhibitor
   Vincristine [ATC:L01CA02]
    D08679  Vincristine (INN)
BRITE hierarchy
Other DBs
CAS: 
57-22-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        60
            1   C1z C    27.1600  -19.2500
            2   C1y C    28.2800  -18.5500
            3   C1y C    27.1600  -20.5100
            4   C8y C    24.9200  -19.2500
            5   C1x C    26.3200  -18.1300
            6   C1z C    29.4000  -19.2500
            7   N1y N    28.2800  -17.2200
            8   C1z C    28.2800  -21.2100
            9   N1y N    26.0400  -21.2100
            10  C8y C    24.9200  -20.5100
            11  C8x C    23.8000  -18.5500
            12  C1x C    26.9500  -17.2200
            13  C1y C    29.4000  -20.5100
            14  C2x C    30.5900  -18.5500
            15  C1b C    30.5200  -19.8800
            16  C1x C    29.4000  -16.5900
            17  C7a C    29.1900  -22.3300
            18  O1a O    27.7900  -23.1000
            19  C4a C    25.4100  -22.2600
            20  C8x C    23.8000  -21.2100
            21  C8y C    22.6800  -19.2500
            22  O7a O    31.8500  -21.4200
            23  C2x C    30.5900  -17.2200
            24  C1a C    31.6400  -19.2500
            25  O7a O    29.1900  -23.6600
            26  C8y C    22.6800  -20.5100
            27  C1z C    20.1600  -16.8700
            28  C7a C    33.1800  -21.4200
            29  C1a C    28.0000  -24.3600
            30  O2a O    21.5600  -21.1400
            31  C8y C    19.0400  -16.1000
            32  C1x C    21.4200  -16.1000
            33  C7a C    19.8100  -18.1300
            34  C1a C    33.8100  -20.3000
            35  O6a O    33.8100  -22.5400
            36  C1a C    20.4400  -20.5100
            37  C8y C    19.0400  -14.7700
            38  N4x N    17.9200  -16.7300
            39  C1y C    21.4200  -14.8400
            40  O7a O    18.3400  -18.6200
            41  O6a O    20.6500  -19.1800
            42  C8y C    16.7300  -14.7700
            43  C1x C    18.3400  -13.6500
            44  C8y C    16.7300  -16.1000
            45  C1x C    20.3000  -14.2100
            46  C1x C    22.6100  -14.0000
            47  C1a C    17.5000  -20.0200
            48  C8x C    15.6100  -14.0700
            49  C1x C    19.1100  -12.6700
            50  C8x C    15.6100  -16.7300
            51  N1y N    20.3000  -12.9500
            52  C1z C    22.5400  -12.8800
            53  C8x C    14.4900  -14.7700
            54  C8x C    14.4900  -16.1000
            55  C1x C    21.4200  -12.1800
            56  C1b C    24.0800  -13.3700
            57  O1a O    23.3800  -11.5500
            58  C1a C    25.1300  -12.7400
            59  O6a O    30.5200  -21.8400
            60  O4a O    24.0100  -22.2600
BOND        68
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 2
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    6  14 1
            14    6  15 1 #Down
            15    7  16 1
            16    8  17 1 #Down
            17    8  18 1 #Up
            18    9  19 1
            19   10  20 1
            20   11  21 2
            21   13  22 1 #Up
            22   14  23 2
            23   15  24 1
            24   17  25 1
            25   20  26 2
            26   27  21 1 #Down
            27   22  28 1
            28   25  29 1
            29   26  30 1
            30   27  31 1
            31   27  32 1
            32   27  33 1 #Up
            33   28  34 1
            34   28  35 2
            35   30  36 1
            36   31  37 2
            37   31  38 1
            38   32  39 1
            39   33  40 1
            40   33  41 2
            41   37  42 1
            42   37  43 1
            43   38  44 1
            44   39  45 1 #Down
            45   39  46 1
            46   40  47 1
            47   42  48 1
            48   43  49 1
            49   44  50 1
            50   51  45 1 #Down
            51   46  52 1
            52   48  53 2
            53   50  54 2
            54   51  55 1
            55   52  56 1 #Down
            56   52  57 1 #Up
            57   56  58 1
            58    7  12 1
            59    8  13 1
            60    9  10 1
            61   16  23 1
            62   21  26 1
            63   42  44 2
            64   49  51 1
            65   52  55 1
            66   53  54 1
            67   17  59 2
            68   19  60 2

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