KEGG   DRUG: D08687Help
Entry
D08687                      Drug                                   
Name
Ziprasidone (INN);
Zipradon (TN)
Formula
C21H21ClN4OS
Exact mass
412.1125
Mol weight
412.9356
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic
Remark
Same as: 
ATC code: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AE Indole derivatives
     N05AE04 Ziprasidone
      D08687  Ziprasidone (INN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Ziprasidone
    D08687  Ziprasidone (INN)
 Bipolar Agents
  Bipolar Agents, Other
   Ziprasidone
    D08687  Ziprasidone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Ziprasidone [ATC:N05AE04]
      D08687  Ziprasidone (INN)
   Serotonin
    5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
     Ziprasidone [ATC:N05AE04]
      D08687  Ziprasidone (INN)
BRITE hierarchy
Other DBs
CAS: 
146939-27-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    14.0678  -14.6282
            2   C8y C    12.8079  -15.1881
            3   N1y N    15.1877  -15.3281
            4   N5x N    14.0678  -13.2283
            5   C8y C    11.8281  -14.1382
            6   C8x C    12.3880  -16.5180
            7   C1x C    15.1877  -16.7279
            8   C1x C    16.4475  -14.5582
            9   S2x S    12.5280  -12.9484
            10  C8x C    10.4982  -14.4182
            11  C8x C    10.9881  -16.7979
            12  C1x C    16.5175  -17.3579
            13  C1x C    17.7074  -15.2581
            14  C8x C    10.0783  -15.8180
            15  N1y N    17.7074  -16.6579
            16  C1b C    18.8973  -17.3579
            17  C1b C    20.0171  -16.6579
            18  C8y C    21.2070  -17.3579
            19  C8x C    22.4669  -16.6579
            20  C8y C    21.2070  -18.7577
            21  C8y C    23.6567  -17.3579
            22  C8x C    22.4669  -19.4576
            23  X   Cl   20.0171  -19.4576
            24  C8y C    23.6567  -18.7577
            25  C1x C    24.9866  -16.9379
            26  N1x N    24.9866  -19.1777
            27  C5x C    25.8265  -18.0578
            28  O5x O    27.2263  -18.0578
BOND        32
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    8  13 1
            13   10  14 2
            14   12  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 2
            19   18  20 1
            20   19  21 1
            21   20  22 2
            22   20  23 1
            23   21  24 2
            24   21  25 1
            25   24  26 1
            26   25  27 1
            27   27  28 2
            28    5   9 1
            29   11  14 1
            30   13  15 1
            31   22  24 1
            32   26  27 1

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