KEGG   DRUG: D08688Help
Entry
D08688                      Drug                                   

Name
Zofenopril (INN);
Zofenil (TN)
Formula
C22H23NO4S2
Exact mass
429.1069
Mol weight
429.5523
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
ACE-inhibitor
Remark
ATC code: 
Drug group: 
Comment
prodrug, active substance: Zofenoprilat
Target
angiotensin-converting enzyme (ACE) inhibitor [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system  
 
Interaction
Transporter inhibition: SCL15A2 [HSA:6565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA15 Zofenopril
      D08688  Zofenopril (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   angiotensin-converting enzyme (ACE)
    Zofenopril
     D08688  Zofenopril (INN)
BRITE hierarchy
Other DBs
CAS: 
81872-10-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   N1y N    25.7600  -18.9000
            2   C1x C    27.0900  -19.4600
            3   C1y C    25.9700  -17.5000
            4   C5a C    24.5700  -19.6000
            5   C1y C    28.0000  -18.4100
            6   C1x C    27.3000  -17.1500
            7   C6a C    25.9000  -16.1000
            8   C1c C    23.3800  -18.9000
            9   O5a O    24.5700  -21.0000
            10  O6a O    27.1600  -15.3300
            11  O6a O    24.7100  -15.4000
            12  C1b C    22.1200  -19.6000
            13  C1a C    23.3800  -17.5000
            14  S2a S    29.4000  -18.4800
            15  S2a S    20.9300  -18.9000
            16  C5a C    19.7400  -19.6000
            17  C8y C    18.4800  -18.9000
            18  O5a O    19.7400  -21.0000
            19  C8x C    18.4800  -17.5000
            20  C8x C    17.2900  -16.8000
            21  C8x C    16.1000  -17.5000
            22  C8x C    16.1000  -18.9000
            23  C8x C    17.2900  -19.6000
            24  C8y C    30.1700  -17.2900
            25  C8x C    31.5700  -17.2900
            26  C8x C    32.2700  -16.1000
            27  C8x C    31.5700  -14.8400
            28  C8x C    30.1700  -14.8400
            29  C8x C    29.4700  -16.1000
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1 #Down
            7     4   8 1
            8     4   9 2
            9     7  10 1
            10    7  11 2
            11    8  12 1
            12    8  13 1 #Up
            13    5   6 1
            14    5  14 1 #Down
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   16  18 2
            19   17  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   17  23 1
            25   14  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   24  29 1

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