KEGG   DRUG: D08690Help
Entry
D08690                      Drug                                   

Name
Zolpidem (INN);
Sanval (TN)
Formula
C19H21N3O
Exact mass
307.1685
Mol weight
307.3895
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hypnotic
Remark
Same as: 
ATC code: 
Drug group: 
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF02 Zolpidem
      D08690  Zolpidem (INN)
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Zolpidem
    D08690  Zolpidem (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Zolpidem
      D08690  Zolpidem (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Zolpidem
    D08690  Zolpidem (INN)
  CYP2C9
   Zolpidem
    D08690  Zolpidem (INN)
  CYP3A4
   Zolpidem
    D08690  Zolpidem (INN)
   Zolpidem
    D08690  Zolpidem (INN)
  CYP3A5
   Zolpidem
    D08690  Zolpidem (INN)
  CYP3A7
   Zolpidem
    D08690  Zolpidem (INN)
BRITE hierarchy
Other DBs
CAS: 
82626-48-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    23.4500  -17.1500
            2   C8y C    24.2900  -16.0300
            3   N4y N    22.1200  -16.6600
            4   C1b C    23.4500  -18.5500
            5   C8y C    25.6900  -16.0300
            6   N5x N    23.4500  -14.8400
            7   C8y C    22.1200  -15.2600
            8   C8x C    20.9300  -17.3600
            9   C5a C    24.6400  -19.1800
            10  C8x C    26.3900  -17.2200
            11  C8x C    26.3900  -14.7700
            12  C8x C    20.9300  -14.5600
            13  C8y C    19.6700  -16.6600
            14  N1c N    24.6400  -20.5800
            15  O5a O    25.9000  -18.4800
            16  C8x C    27.7900  -17.2200
            17  C8x C    27.7900  -14.7700
            18  C8x C    19.6700  -15.2600
            19  C1a C    18.4800  -17.3600
            20  C1a C    25.9000  -21.2800
            21  C1a C    23.4500  -21.2800
            22  C8y C    28.4900  -16.0300
            23  C1a C    29.8900  -16.0300
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    7  12 1
            12    8  13 2
            13    9  14 1
            14    9  15 2
            15   10  16 1
            16   11  17 2
            17   12  18 2
            18   13  19 1
            19   14  20 1
            20   14  21 1
            21   16  22 2
            22   22  23 1
            23    6   7 2
            24   13  18 1
            25   17  22 1

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