KEGG   DRUG: ZolpidemHelp
Entry
D08690                      Drug                                   

Name
Zolpidem (INN);
Sanval (TN)
Formula
C19H21N3O
Exact mass
307.1685
Mol weight
307.3895
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01836  Non-benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Efficacy
Sedative-hypnotic
Comment
Imidazopyridines
Target
GABRA/GABRB/GABRD/GABRE/GABRG/GABRP/GABRQ [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2C9 [HSA:1559], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF02 Zolpidem
      D08690  Zolpidem (INN)
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Zolpidem
    D08690  Zolpidem (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Zolpidem
      D08690  Zolpidem (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Zolpidem
    D08690  Zolpidem (INN)
  CYP2C9
   Zolpidem
    D08690  Zolpidem (INN)
  CYP3A4
   Zolpidem
    D08690  Zolpidem (INN)
BRITE hierarchy
Other DBs
CAS: 
82626-48-0
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    23.4500  -17.1500
            2   C8y C    24.2900  -16.0300
            3   N4y N    22.1200  -16.6600
            4   C1b C    23.4500  -18.5500
            5   C8y C    25.6900  -16.0300
            6   N5x N    23.4500  -14.8400
            7   C8y C    22.1200  -15.2600
            8   C8x C    20.9300  -17.3600
            9   C5a C    24.6400  -19.1800
            10  C8x C    26.3900  -17.2200
            11  C8x C    26.3900  -14.7700
            12  C8x C    20.9300  -14.5600
            13  C8y C    19.6700  -16.6600
            14  N1c N    24.6400  -20.5800
            15  O5a O    25.9000  -18.4800
            16  C8x C    27.7900  -17.2200
            17  C8x C    27.7900  -14.7700
            18  C8x C    19.6700  -15.2600
            19  C1a C    18.4800  -17.3600
            20  C1a C    25.9000  -21.2800
            21  C1a C    23.4500  -21.2800
            22  C8y C    28.4900  -16.0300
            23  C1a C    29.8900  -16.0300
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    7  12 1
            12    8  13 2
            13    9  14 1
            14    9  15 2
            15   10  16 1
            16   11  17 2
            17   12  18 2
            18   13  19 1
            19   14  20 1
            20   14  21 1
            21   16  22 2
            22   22  23 1
            23    6   7 2
            24   13  18 1
            25   17  22 1

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