KEGG   DRUG: D08691Help
Entry
D08691                      Drug                                   

Name
Zuclopenthixol acetate;
Cisordinol-acutard (TN)
Formula
C24H27ClN2O2S
Exact mass
442.1482
Mol weight
443.0014
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic
Remark
ATC code: 
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
dopamine D1-receptor antagonist [HSA:1812] [KO:K04144]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AF Thioxanthene derivatives
     N05AF05 Zuclopenthixol
      D08691  Zuclopenthixol acetate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D1-receptor [HSA:1812] [KO:K04144]
     Zuclopenthixol [ATC:N05AF05]
      D08691  Zuclopenthixol acetate
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Zuclopenthixol [ATC:N05AF05]
      D08691  Zuclopenthixol acetate
BRITE hierarchy
Other DBs
CAS: 
85721-05-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C8x C    19.1182  -20.7993
            2   C8x C    19.1182  -22.1999
            3   C8x C    20.3788  -22.9002
            4   C8y C    21.5693  -22.1999
            5   C8y C    21.5693  -20.7993
            6   C8x C    20.3788  -20.0989
            7   S2x S    22.7599  -22.9002
            8   C8y C    24.0205  -22.1999
            9   C8y C    24.0205  -20.7993
            10  C8y C    22.7599  -20.0989
            11  C8x C    25.2110  -22.9002
            12  C8x C    26.4015  -22.1999
            13  C8y C    26.4015  -20.7993
            14  C8x C    25.2110  -20.0989
            15  C2b C    22.7599  -18.6983
            16  C1b C    24.0205  -17.9980
            17  C1b C    24.0205  -16.5973
            18  N1y N    25.2110  -15.8970
            19  C1x C    26.4015  -16.5973
            20  C1x C    27.5921  -15.8970
            21  N1y N    27.5921  -14.4964
            22  C1x C    26.4015  -13.7961
            23  C1x C    25.2110  -14.4964
            24  C1b C    28.8527  -13.7961
            25  C1b C    30.0432  -14.4964
            26  O7a O    31.2337  -13.7961
            27  X   Cl   27.6621  -20.0989
            28  C7a C    32.4524  -14.4865
            29  C1a C    33.6343  -13.7911
            30  O6a O    32.4641  -15.8964
BOND        33
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    8  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16    9  14 1
            17   10  15 2
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   18  23 1
            27   21  24 1
            28   24  25 1
            29   25  26 1
            30   13  27 1
            31   26  28 1
            32   28  29 1
            33   28  30 2

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