KEGG   DRUG: D08768Help
Entry
D08768                      Drug                                   

Name
Promethazine hibenzate;
Hiberna (TN)
Formula
C17H20N2S. C14H10O4
Exact mass
526.1926
Mol weight
526.6459
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
Therapeutic category: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antipsychotics
Phenothiazines
Hypnotics
Histamine H1 receptor antagonists
Dopamine receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4413  Phenothiazines
     D08768  Promethazine hibenzate
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D08768  Promethazine hibenzate
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D08768  Promethazine hibenzate
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Promethazine
    D08768  Promethazine hibenzate
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Promethazine
    D08768  Promethazine hibenzate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Promethazine [ATC:D04AA10 R06AD02]
      D08768  Promethazine hibenzate
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        38
            1   N1y N    13.3578  -16.8634
            2   C8y C    14.5975  -17.5618
            3   C8y C    12.1647  -17.5618
            4   C1b C    13.3578  -15.4492
            5   C8y C    14.5975  -18.9703
            6   C8x C    15.7906  -16.8634
            7   C8y C    12.1647  -18.9703
            8   C8x C    10.9658  -16.8634
            9   C1c C    14.5626  -14.7623
            10  S2x S    13.3578  -19.6627
            11  C8x C    15.7906  -19.6627
            12  C8x C    16.9954  -17.5618
            13  C8x C    10.9658  -19.6627
            14  C8x C     9.7261  -17.5618
            15  N1c N    14.5626  -13.4411
            16  C1a C    15.7557  -15.4492
            17  C8x C    16.9954  -18.9703
            18  C8x C     9.7261  -18.9703
            19  C1a C    13.2240  -12.6671
            20  C1a C    15.6975  -12.7020
            21  C8x C    19.1083  -17.5688
            22  C8x C    19.1083  -18.9687
            23  C8x C    20.3206  -19.6686
            24  C8x C    21.5330  -18.9687
            25  C8y C    21.5330  -17.5688
            26  C8y C    20.3206  -16.8689
            27  C8x C    23.9576  -18.9687
            28  C8y C    23.9576  -17.5688
            29  C5a C    22.7453  -16.8689
            30  C8x C    25.1700  -19.6686
            31  C8y C    26.3823  -18.9687
            32  C8x C    26.3823  -17.5688
            33  C8x C    25.1700  -16.8689
            34  O1a O    27.5987  -19.6709
            35  O5a O    22.7453  -15.4690
            36  C6a C    20.3206  -15.4692
            37  O6a O    19.0915  -14.7593
            38  O6a O    21.5161  -14.7788
BOND        41
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   27  28 2
            30   28  29 1
            31   25  29 1
            32   27  30 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   28  33 1
            37   31  34 1
            38   29  35 2
            39   26  36 1
            40   36  37 2
            41   36  38 1

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