KEGG   DRUG: D08864Help
Entry
D08864                      Drug                                   

Name
Azilsartan (JAN/USAN/INN);
Azilva (TN)
Formula
C25H20N4O5
Exact mass
456.1434
Mol weight
456.4501
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of hypertension
Remark
Therapeutic category: 
Target
angiotensin II receptor type 1 (AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Interaction
Drug interaction
Brite
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Azilsartan
    D08864  Azilsartan (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D08864  Azilsartan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Azilsartan
      D08864  Azilsartan (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
147403-03-0
PubChem: 
LigandBox: 
KCF data Show

ATOM        34
            1   C8y C    22.2302  -17.2042
            2   N4y N    21.8107  -15.8755
            3   C8y C    23.6288  -17.2042
            4   C8y C    21.5309  -18.3929
            5   C8y C    22.9295  -15.0364
            6   C1b C    20.6219  -15.1762
            7   N5x N    24.1183  -15.8755
            8   C8x C    24.3281  -18.3929
            9   C8x C    22.2302  -19.5817
            10  C6a C    20.8317  -19.5817
            11  O2a O    22.9295  -13.6378
            12  C8y C    19.3632  -15.8755
            13  C8x C    23.6288  -19.5817
            14  O6a O    21.5309  -20.8404
            15  C1b C    24.1882  -12.9385
            16  C8x C    18.1744  -15.2461
            17  C8x C    19.3631  -17.2741
            18  C1a C    24.1882  -11.5399
            19  C8x C    16.9856  -15.9454
            20  C8x C    18.2443  -18.0433
            21  C8y C    16.9856  -17.3440
            22  C8y C    15.7968  -18.0433
            23  C8y C    14.5381  -17.4139
            24  C8x C    15.7968  -19.4419
            25  C8y C    14.5381  -15.9454
            26  C8x C    13.4193  -18.1132
            27  C8x C    14.6080  -20.2111
            28  N4x N    13.4192  -15.1762
            29  N5x N    15.6569  -15.1063
            30  C8x C    13.4192  -19.5118
            31  C8y C    13.8388  -13.8476
            32  O7x O    15.2374  -13.8476
            33  O6a O    12.9842  -12.7405
            34  O6a O    19.4332  -19.5645
BOND        38
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    8  13 2
            13   10  14 2
            14   11  15 1
            15   12  16 1
            16   12  17 2
            17   15  18 1
            18   16  19 2
            19   17  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 1
            25   23  26 2
            26   24  27 1
            27   25  28 1
            28   25  29 2
            29   26  30 1
            30   28  31 1
            31   29  32 1
            32    5   7 2
            33    9  13 1
            34   20  21 2
            35   27  30 2
            36   31  32 1
            37   31  33 2
            38   10  34 1

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