KEGG   DRUG: D08877Help
Entry
D08877                      Drug                                   

Name
Briobacept (USAN)
Formula
C2910H4542N814O878S24
Exact mass
65706.9083
Mol weight
65747.6875
Sequence
DVRRGPRSLR GRDAPAPTPC NPAECFDPLV RHCVACGLLR TPRPKPAGAS SPAPRTALQP
QESVGAGAGE AAVDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS
HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA
LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP
ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPG
(disulfide brige, dimer: 79-79'; 82-82')
  Type
Peptide
Activity
Treatment of autoimmune disease
Comment
Briobacept is a fusion protein consisting of human BR3 [HSA:115650] [KO:K05151] and human IgG1 Fc.
Target
BAFF [HSA:10673] [KO:K05476]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   BAFF
    Briobacept
     D08877  Briobacept (USAN)
BRITE hierarchy
Other DBs
CAS: 
869881-54-9
PubChem: 

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