KEGG   DRUG: D08881Help
Entry
D08881                      Drug                                   

Name
Cediranib (USAN/INN)
Formula
C25H27FN4O3
Exact mass
450.2067
Mol weight
450.5053
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of cancer
Remark
Drug group: 
Comment
angiogenesis inhibitor
Target
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091];
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Cediranib
      D08881  Cediranib (USAN/INN)
    PDGFRB tyrosine kinase
     Cediranib
      D08881  Cediranib (USAN/INN)
    c-KIT tyrosine kinase
     Cediranib
      D08881  Cediranib (USAN/INN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Cediranib
      D08881  Cediranib (USAN/INN)
    VEGFR2 tyrosine kinase
     Cediranib
      D08881  Cediranib (USAN/INN)
    VEGFR3 tyrosine kinase
     Cediranib
      D08881  Cediranib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
288383-20-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C8y C    17.5474  -15.6104
            2   C8y C    17.5474  -14.2048
            3   C8x C    18.7421  -16.3131
            4   C8y C    16.2825  -16.3131
            5   N5x N    16.2825  -13.5020
            6   C8x C    18.7421  -13.5020
            7   C8y C    19.9369  -15.6104
            8   N5x N    15.0877  -15.6104
            9   C8x C    15.0877  -14.2048
            10  C8y C    19.9369  -14.2048
            11  O2a O    21.2018  -16.3131
            12  O2a O    21.2018  -13.5020
            13  C1a C    22.3965  -15.6104
            14  C1b C    22.3965  -14.2048
            15  O2a O    16.3352  -17.7186
            16  C8y C    15.0525  -18.3989
            17  C8y C    13.8286  -17.6717
            18  C8y C    12.6026  -18.3591
            19  C8y C    12.5852  -19.7645
            20  C8x C    13.8089  -20.4918
            21  C8x C    15.0348  -19.8044
            22  C8x C    11.2714  -17.9079
            23  C8y C    10.4310  -19.0345
            24  N4x N    11.2428  -20.1820
            25  C1a C     9.0444  -19.0173
            26  X   F    13.8467  -16.2430
            27  C1b C    23.6195  -13.5120
            28  C1b C    24.8055  -14.2098
            29  N1y N    26.0157  -13.5241
            30  C1x C    27.2577  -14.0891
            31  C1x C    28.1788  -13.0824
            32  C1x C    27.5061  -11.8953
            33  C1x C    26.1692  -12.1684
BOND        37
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11   10  12 1
            12   11  13 1
            13   12  14 1
            14    7  10 1
            15    8   9 1
            16    4  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   18  22 1
            25   22  23 2
            26   23  24 1
            27   19  24 1
            28   23  25 1
            29   17  26 1
            30   14  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   29  33 1

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