KEGG   DRUG: D08890Help
Entry
D08890                      Drug                                   

Name
Choline fenofibrate (USAN/INN);
Fenofibric acid (TN);
Trilipix (TN)
Product
  Generic
Formula
C17H14ClO4. C5H14NO
Exact mass
421.1656
Mol weight
421.9144
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Lipid-lowering agent, Antihyperlipidemic
Remark
ATC code: 
Target
peroxisome proliferator-activated receptor (PPAR) alpha agonist [HSA:5465] [KO:K07294]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB11 Choline fenofibrate
      D08890  Choline fenofibrate (USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Fibric Acid Derivatives
   Choline fenofibrate
    D08890  Choline fenofibrate (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha
     Choline fenofibrate
      D08890  Choline fenofibrate (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C9
   Choline fenofibrate
    D08890  Choline fenofibrate (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
856676-23-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        29
            1   C8y C    18.3598  -16.7433
            2   C5a C    17.1689  -17.4439
            3   C8x C    19.6208  -17.4439
            4   C8x C    18.3598  -15.3422
            5   C8y C    15.9779  -16.7433
            6   O5a O    17.1689  -18.8450
            7   C8x C    20.8118  -16.7433
            8   C8x C    19.6208  -14.6417
            9   C8x C    14.7169  -17.4439
            10  C8x C    15.9779  -15.3422
            11  C8y C    20.8118  -15.3422
            12  C8x C    13.5260  -16.7433
            13  C8x C    14.7169  -14.6417
            14  O2a O    22.0027  -14.6417
            15  C8y C    13.5260  -15.3422
            16  C1d C    23.2637  -15.3422
            17  X   Cl   12.3350  -14.6417
            18  C6a C    24.4547  -14.6417
            19  O6a O    25.6456  -15.3422 #-
            20  O6a O    24.4547  -13.2406
            21  C1a C    22.5632  -16.5332
            22  C1a C    23.9643  -16.5332
            23  C1a C    29.8900  -16.7300
            24  N1d N    31.0800  -16.0300 #+
            25  C1b C    32.3400  -16.7300
            26  C1b C    33.5300  -16.0300
            27  O1a O    34.7200  -16.7300
            28  C1a C    31.0800  -14.6300
            29  C1a C    31.0800  -17.4300
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 2
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   18  20 2
            20    8  11 1
            21   13  15 1
            22   16  21 1
            23   16  22 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   24  28 1
            29   24  29 1

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