KEGG   DRUG: ClevidipineHelp
Entry
D08892                      Drug                                   

Name
Clevidipine (USAN/INN);
Clevidipine butyrate;
Cleviprex (TN)
Product
Formula
C21H23Cl2NO6
Exact mass
455.0902
Mol weight
456.3164
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Remark
ATC code: C08CA16
Product: D08892<US>
Efficacy
Antihypertensive, Calcium channel blocker
  Disease
High blood pressure [DS:H01633]
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA16 Clevidipine
      D08892  Clevidipine (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D08892  Clevidipine (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D08892
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08892
BRITE hierarchy
Other DBs
CAS: 167221-71-8
PubChem: 96025575
ChEMBL: CHEMBL1237132
LigandBox: D08892
NIKKAJI: J772.200A
KCF data Show

ATOM        30
            1   C2y C    22.3404  -13.2197
            2   C2y C    22.3404  -14.6377
            3   C1y C    23.5685  -15.3468
            4   C2y C    24.7966  -14.6377
            5   C2y C    24.7966  -13.2197
            6   N1x N    23.5685  -12.5106
            7   C1a C    26.0436  -12.4995
            8   C1a C    21.1124  -12.5106
            9   C7a C    26.0501  -15.3468
            10  O7a O    27.2783  -14.6377
            11  C1b C    28.5063  -15.3468
            12  O7a O    29.7344  -14.6377
            13  C7a C    30.9625  -15.3468
            14  C1b C    32.1906  -14.6377
            15  C1b C    33.4186  -15.3468
            16  C1a C    34.6468  -14.6377
            17  C7a C    21.1124  -15.3468
            18  O7a O    19.9015  -14.6475
            19  O6a O    21.1123  -16.7646
            20  O6a O    26.0564  -16.4100
            21  O6a O    30.9625  -16.7645
            22  C1a C    18.6987  -15.3418
            23  C8y C    23.5685  -16.7646
            24  C8x C    22.3234  -17.4836
            25  C8x C    22.3235  -18.9017
            26  C8x C    23.5517  -19.6106
            27  C8y C    24.7967  -18.8916
            28  C8y C    24.7966  -17.4736
            29  X   Cl   26.0438  -19.6117
            30  X   Cl   25.9537  -17.4611
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     5   7 1
            8     1   8 1
            9     4   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17    2  17 1
            18   17  18 1
            19   17  19 2
            20    9  20 2
            21   13  21 2
            22   18  22 1
            23    3  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   23  28 1
            30   27  29 1
            31   28  30 1

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