KEGG   DRUG: D08907Help
Entry
D08907                      Drug                                   

Name
Dovitinib lactate hydrate (JAN);
Dovitinib lactate (USAN)
Formula
C21H21FN6O. C3H6O3. H2O
Exact mass
500.2183
Mol weight
500.5227
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of cancer
Target
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
fibroblast growth factor receptor 1 (FGFR1) inhibitor [HSA:2260] [KO:K04362];
fibroblast growth factor receptor 2 (FGFR2) inhibitor [HSA:2263] [KO:K05093];
fibroblast growth factor receptor 3 (FGFR3) inhibitor [HSA:2261] [KO:K05094]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04510  Focal adhesion  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRB tyrosine kinase
     Dovitinib
      D08907  Dovitinib lactate (USAN)
   RTK class IV (FGF receptor family)
    fibroblast growth factor receptor 1
     Dovitinib
      D08907  Dovitinib lactate (USAN)
    fibroblast growth factor receptor 2
     Dovitinib
      D08907  Dovitinib lactate (USAN)
    fibroblast growth factor receptor 3
     Dovitinib
      D08907  Dovitinib lactate (USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Dovitinib
      D08907  Dovitinib lactate (USAN)
    VEGFR2 tyrosine kinase
     Dovitinib
      D08907  Dovitinib lactate (USAN)
    VEGFR3 tyrosine kinase
     Dovitinib
      D08907  Dovitinib lactate (USAN)
BRITE hierarchy
Other DBs
CAS: 
915769-50-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        36
            1   C8x C     9.5696  -19.3790
            2   C8x C     9.5696  -20.7836
            3   C8x C    10.7860  -21.4858
            4   C8y C    12.0024  -20.7836
            5   C8y C    12.0024  -19.3790
            6   C8y C    10.7860  -18.6767
            7   N4x N    13.2188  -21.4858
            8   C8y C    14.4351  -20.7836
            9   C8y C    14.4351  -19.3790
            10  C8y C    13.2188  -18.6767
            11  X   F    10.7860  -17.2723
            12  N1a N    13.2188  -17.2721
            13  C8y C    15.6367  -18.6852
            14  N5x N    16.8937  -19.2448
            15  C8y C    17.8145  -18.2221
            16  C8y C    17.1265  -17.0304
            17  N4x N    15.7804  -17.3166
            18  C8x C    19.2191  -18.2221
            19  C8x C    19.9214  -17.0058
            20  C8y C    19.2333  -15.8140
            21  C8x C    17.8287  -15.8140
            22  O5x O    15.6367  -21.4773
            23  N1y N    19.9494  -14.5729
            24  C1x C    21.3677  -14.5722
            25  C1x C    22.0694  -13.3556
            26  N1y N    21.3665  -12.1395
            27  C1x C    19.9483  -12.1401
            28  C1x C    19.2465  -13.3569
            29  C1a C    22.0661  -10.9266
            30  C6a C    23.2642  -19.0278
            31  O6a O    24.4805  -19.7301
            32  C1c C    22.0478  -19.7301
            33  O1a O    20.8484  -19.0375
            34  C1a C    22.0477  -21.1345
            35  O6a O    23.2642  -17.6233
            36  O0  O    27.6184  -18.1149
BOND        38
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    6  11 1
            13   10  12 1
            14    9  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   13  17 1
            20   15  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   16  21 2
            25    8  22 2
            26   20  23 1
            27   23  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   23  28 1
            33   26  29 1
            34   30  31 1
            35   30  32 1
            36   32  33 1
            37   32  34 1
            38   30  35 2

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