KEGG   DRUG: D08947Help
Entry
D08947                      Drug                                   
Name
Motesanib phosphate (JAN);
Motesanib diphosphate (USAN)
Formula
C22H23N5O. 2H3PO4
Exact mass
569.1441
Mol weight
569.4413
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiangiogenesis agent
Comment
angiogenesis inhibitor
Target
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
RET inhibitor [HSA:5979] [KO:K05126];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway  
 
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase [HSA:5156] [KO:K04363]
     Motesanib
      D08947  Motesanib diphosphate (USAN)
    PDGFRB tyrosine kinase [HSA:5159] [KO:K05089]
     Motesanib
      D08947  Motesanib diphosphate (USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
     Motesanib
      D08947  Motesanib diphosphate (USAN)
    VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
     Motesanib
      D08947  Motesanib diphosphate (USAN)
    VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097]
     Motesanib
      D08947  Motesanib diphosphate (USAN)
BRITE hierarchy
Other DBs
CAS: 
857876-30-3
PubChem: 
LigandBox: 
KCF data Show

ATOM        38
            1   C8y C    21.1400  -14.8400
            2   C5a C    22.2600  -15.5400
            3   C8x C    21.1400  -13.4400
            4   C8y C    19.8800  -15.5400
            5   N1b N    23.5200  -14.9100
            6   O5a O    22.2600  -16.9400
            7   C8x C    19.9500  -12.7400
            8   N5x N    18.6900  -14.7700
            9   C8y C    24.7100  -15.6100
            10  C8x C    18.6900  -13.3700
            11  C8x C    25.9000  -14.9100
            12  C8x C    24.7100  -17.0100
            13  C8x C    27.1600  -15.6100
            14  C8y C    25.9000  -17.7100
            15  C8y C    27.1600  -17.0100
            16  N1x N    26.1764  -19.1247
            17  C1x C    27.6072  -19.2990
            18  C1z C    28.2151  -17.9920
            19  C1a C    29.5846  -17.7245
            20  C1a C    29.0752  -19.0907
            21  N1b N    19.8502  -16.9397
            22  C1b C    18.6461  -17.6014
            23  C8y C    17.4155  -16.8564
            24  C8x C    17.4446  -15.4701
            25  C8x C    16.2471  -14.7448
            26  N5x N    15.0202  -15.4193
            27  C8x C    15.0612  -16.8056
            28  C8x C    16.1887  -17.5308
            29  P1b P    34.7900  -16.0300
            30  O1c O    34.7900  -14.6300
            31  O1c O    33.3900  -16.0300
            32  O1c O    34.7900  -17.4300
            33  O1c O    36.1900  -16.0300
            34  P1b P    34.7900  -16.0300
            35  O1c O    34.7900  -14.6300
            36  O1c O    33.3900  -16.0300
            37  O1c O    34.7900  -17.4300
            38  O1c O    36.1900  -16.0300
BOND        39
            1     1   4 1
            2     2   5 1
            3     2   6 2
            4     3   7 1
            5     4   8 2
            6     5   9 1
            7     7  10 2
            8     9  11 2
            9     9  12 1
            10   11  13 1
            11   12  14 2
            12   13  15 2
            13    8  10 1
            14   14  15 1
            15    1   2 1
            16    1   3 2
            17   14  16 1
            18   16  17 1
            19   17  18 1
            20   15  18 1
            21   18  19 1
            22   18  20 1
            23    4  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1
            32   29  30 2
            33   29  31 1
            34   29  32 1
            35   29  33 1
            36   34  35 2
            37   34  36 1
            38   34  37 1
            39   34  38 1
BRACKET     1    32.0600  -18.3400   32.0600  -13.5100
            1    37.6600  -13.5100   37.6600  -18.3400
            1  2
 ORIGINAL  1   29  30  31  32  33
 REPEAT    1   34  35  36  37  38

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