KEGG   DRUG: D08963Help
Entry
D08963                      Drug                                   

Name
Pamapimod (INN/USAN)
Formula
C19H20F2N4O4
Exact mass
406.1453
Mol weight
406.3833
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of rheumatoid arthritis
Target
MAPK14 (p38alpha) inhibitor [HSA:1432] [KO:K04441]
  Pathway
hsa04010  MAPK signaling pathway
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation  
 
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CMGC group
   MAPK family
    p38alpha (MAPK14)
     Pamapimod
      D08963  Pamapimod (INN/USAN)
BRITE hierarchy
Other DBs
CAS: 
449811-01-2
PubChem: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        29
            1   N5x N    18.3400  -18.3400
            2   C8y C    18.3400  -19.7400
            3   N5x N    19.5524  -20.4400
            4   C8y C    20.7649  -19.7400
            5   C8y C    20.7649  -18.3400
            6   C8x C    19.5524  -17.6400
            7   N4y N    21.9773  -20.4400
            8   C8y C    23.1897  -19.7400
            9   C8y C    23.1897  -18.3400
            10  C8x C    21.9773  -17.6400
            11  O2a O    24.3873  -17.6485
            12  C8y C    25.5756  -18.3345
            13  C8x C    25.5757  -19.7398
            14  C8x C    26.7881  -20.4397
            15  C8y C    28.0005  -19.7396
            16  C8x C    28.0004  -18.3344
            17  C8y C    26.7880  -17.6345
            18  N1b N    17.1276  -20.4400
            19  C1c C    15.9151  -19.7400
            20  C1b C    14.7027  -20.4400
            21  C1b C    13.4903  -19.7400
            22  O1a O    12.2927  -20.4315
            23  C1b C    15.9151  -18.3402
            24  C1b C    14.6839  -17.6292
            25  O1a O    13.4789  -18.3248
            26  C1a C    21.9773  -21.8400
            27  O5x O    24.3873  -20.4315
            28  X   F    26.7880  -16.2402
            29  X   F    29.2128  -20.4394
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    2  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   19  23 1
            26   23  24 1
            27   24  25 1
            28    7  26 1
            29    8  27 2
            30   17  28 1
            31   15  29 1

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