KEGG   DRUG: Talaglumetad hydrochlorideHelp
Entry
D09008                      Drug                                   

Name
Talaglumetad hydrochloride (USAN)
Formula
C11H16N2O5. HCl
Exact mass
292.0826
Mol weight
292.7161
Structure
Mol fileKCF fileDB searchJmolKegDraw
Efficacy
Antianxiety, Glutamate metabotropic receptor agonist
Comment
Treatment of anxiety and stress disorders (metabotropic glutamate (mGlu) agonist)
Target
GRM2 [HSA:2912] [KO:K04605];
GRM3 [HSA:2913] [KO:K04605]
  Pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Metabotropic glutamate receptor family
   Glutamate (metabotropic)
    metabotropic glutamate receptor 2/3
     Talaglumetad
      D09008  Talaglumetad hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
441765-97-5
PubChem: 
ChEMBL: 
LigandBox: 
KCF data Show

ATOM        19
            1   C1y C    23.0668  -17.7924
            2   C1y C    23.0668  -19.1869
            3   C1z C    24.3916  -19.6750
            4   C1x C    25.2283  -18.4897
            5   C1x C    24.3916  -17.3740
            6   C1y C    21.8117  -18.4897
            7   C6a C    20.4869  -18.4897
            8   O6a O    19.7896  -17.3043
            9   O6a O    19.7896  -19.7447
            10  C6a C    25.5770  -20.3723
            11  N1b N    24.3916  -21.0696
            12  O6a O    26.7623  -19.6750
            13  O6a O    25.5770  -21.7668
            14  C5a C    23.1839  -21.7668
            15  C1c C    23.1839  -23.1614
            16  C1a C    21.9931  -23.8491
            17  O5a O    21.9931  -21.0791
            18  N1a N    24.4082  -23.8684
            19  X   Cl   30.3184  -20.2328
BOND        19
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     2   6 1
            8     6   7 1 #Up
            9     7   8 1
            10    7   9 2
            11    3  10 1 #Up
            12    3  11 1 #Down
            13   10  12 1
            14   10  13 2
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   14  17 2
            19   15  18 1 #Up

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