KEGG   DRUG: D09215Help
Entry
D09215                      Drug                                   

Name
Eslicarbazepine (USAN/INN)
Formula
C15H14N2O2
Exact mass
254.1055
Mol weight
254.2839
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant;
Antiepileptic
Remark
ATC code: 
Drug group: 
Comment
Active metabolite of oxcarbazepine [DR:D00533]
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
  Pathway
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF04 Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Eslicarbazepine
    D09215  Eslicarbazepine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
    voltage-gated sodium channel (SCN2A)
     Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
    voltage-gated sodium channel (SCN3A)
     Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
    voltage-gated sodium channel (SCN4A)
     Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
    voltage-gated sodium channel (SCN5A)
     Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
    voltage-gated sodium channel (SCN8A)
     Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
    voltage-gated sodium channel (SCN9A)
     Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
104746-04-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        19
            1   C8y C    26.3200  -20.6500
            2   N1y N    27.5800  -20.0200
            3   C8y C    28.8400  -20.6500
            4   C8y C    29.1200  -21.9800
            5   C8y C    26.0400  -22.0500
            6   C1x C    28.2800  -23.1000
            7   C1y C    26.8800  -23.1000
            8   C8x C    25.2700  -19.6700
            9   C8x C    23.9400  -20.1600
            10  C8x C    23.6600  -21.4900
            11  C8x C    24.7100  -22.4700
            12  C8x C    30.5200  -22.3300
            13  C8x C    31.5000  -21.3500
            14  C8x C    31.1500  -20.0200
            15  C8x C    29.7500  -19.6000
            16  C5a C    27.5800  -18.6200
            17  O5a O    26.3900  -17.9200
            18  N1a N    28.7700  -17.9200
            19  O1a O    26.2500  -24.3600
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1
            21    7  19 1 #Down

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