Entry |
|
Name |
Eslicarbazepine (USAN/INN) |
Formula |
C15H14N2O2
|
Exact mass |
254.1055
|
Mol weight |
254.2839
|
Structure |
|
Simcomp |
|
Class |
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02034 Carboxamide antiepileptic
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
|
Remark |
Product (DG00848): | D09612<US> |
|
Efficacy |
Anticonvulsant, Antiepileptic |
Comment |
Carboxamide derivative
Active metabolite of oxcarbazepine [DR: D00533]
|
Target |
|
Pathway |
|
Interaction |
CYP inhibition: CYP2C19 [HSA: 1557]
CYP induction: CYP3A4 [HSA: 1576]
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AF Carboxamide derivatives
N03AF04 Eslicarbazepine
D09215 Eslicarbazepine (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02034 Carboxamide antiepileptic
DG00848 Eslicarbazepine
D09215 Eslicarbazepine
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
DG00848 Eslicarbazepine
D09215 Eslicarbazepine
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00848 Eslicarbazepine
D09215 Eslicarbazepine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D09215 Eslicarbazepine (USAN/INN)
SCN2A
D09215 Eslicarbazepine (USAN/INN)
SCN3A
D09215 Eslicarbazepine (USAN/INN)
SCN4A
D09215 Eslicarbazepine (USAN/INN)
SCN5A
D09215 Eslicarbazepine (USAN/INN)
SCN8A
D09215 Eslicarbazepine (USAN/INN)
SCN9A
D09215 Eslicarbazepine (USAN/INN)
SCN10A
D09215 Eslicarbazepine (USAN/INN)
SCN11A
D09215 Eslicarbazepine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09215
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02034 Carboxamide antiepileptic
DG00848 Eslicarbazepine
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
DG00848 Eslicarbazepine
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00848 Eslicarbazepine
|
Other DBs |
|
KCF data |
ATOM 19
1 C8y C 26.3200 -20.6500
2 N1y N 27.5800 -20.0200
3 C8y C 28.8400 -20.6500
4 C8y C 29.1200 -21.9800
5 C8y C 26.0400 -22.0500
6 C1x C 28.2800 -23.1000
7 C1y C 26.8800 -23.1000
8 C8x C 25.2700 -19.6700
9 C8x C 23.9400 -20.1600
10 C8x C 23.6600 -21.4900
11 C8x C 24.7100 -22.4700
12 C8x C 30.5200 -22.3300
13 C8x C 31.5000 -21.3500
14 C8x C 31.1500 -20.0200
15 C8x C 29.7500 -19.6000
16 C5a C 27.5800 -18.6200
17 O5a O 26.3900 -17.9200
18 N1a N 28.7700 -17.9200
19 O1a O 26.2500 -24.3600
BOND 21
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 1 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 5 11 2
13 4 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 15 3 2
18 2 16 1
19 16 17 2
20 16 18 1
21 7 19 1 #Down
|