KEGG   DRUG: IndeglitazarHelp
Entry
D09350                      Drug                                   

Name
Indeglitazar (USAN)
Formula
C19H19NO6S
Exact mass
389.0933
Mol weight
389.4223
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01732  Non-thiazolidinedione type PPAR agonist
Other
 DG01733  PPAR agonist
  DG01732  Non-thiazolidinedione type PPAR agonist
Activity
Treatment of type II diabetes
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294];
NR1C2 (PPARD) [HSA:5467] [KO:K04504];
NR1C3 (PPARG) [HSA:5468] [KO:K08530]
  Pathway
PPAR signaling pathway
Adipocytokine signaling pathway
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha
     Indeglitazar
      D09350  Indeglitazar (USAN)
    peroxisome proliferator-activated receptor (PPAR) delta
     Indeglitazar
      D09350  Indeglitazar (USAN)
    peroxisome proliferator-activated receptor (PPAR) gamma
     Indeglitazar
      D09350  Indeglitazar (USAN)
BRITE hierarchy
Other DBs
CAS: 
835619-41-5
PubChem: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8x C    11.5500  -23.3100
            2   C8y C    11.5500  -24.7100
            3   C8x C    12.7400  -25.4100
            4   C8x C    14.0000  -24.7100
            5   C8y C    14.0000  -23.3100
            6   C8x C    12.7400  -22.6100
            7   O2a O    10.3600  -25.4100
            8   C1a C     9.1700  -24.7100
            9   S4a S    15.1900  -22.6100
            10  N4y N    16.3800  -23.3100
            11  C8y C    16.8000  -24.6400
            12  C8y C    18.2000  -24.6400
            13  C8y C    18.6900  -23.3100
            14  C8x C    17.5700  -22.4700
            15  C8x C    16.1000  -25.8300
            16  C8x C    16.7300  -27.0900
            17  C8y C    18.2000  -27.0900
            18  C8x C    18.9000  -25.9000
            19  O2a O    18.8300  -28.3500
            20  C1a C    20.2300  -28.3500
            21  O3c O    14.4900  -21.4200
            22  O3c O    15.8900  -21.4200
            23  C1b C    19.8800  -22.6100
            24  C1b C    21.0700  -23.3100
            25  C6a C    22.2600  -22.6100
            26  O6a O    23.4500  -23.3100
            27  O6a O    22.2600  -21.2100
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 2
            15   10  14 1
            16   11  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   12  18 2
            21   17  19 1
            22   19  20 1
            23    9  21 2
            24    9  22 2
            25   23  24 1
            26   23  13 1
            27   24  25 1
            28   25  26 1
            29   25  27 2

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