KEGG   DRUG: D09377Help
Entry
D09377                      Drug                                   

Name
Semagacestat (USAN/INN)
Formula
C19H27N3O4
Exact mass
361.2002
Mol weight
361.4354
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of Alzheimer's disease
Target
gamma-secretase inhibitor [HSA:51107 5663 23385 55851] [KO:K06172 K04505 K06171 K06170]
  Pathway
hsa04330  Notch signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa05010  Alzheimer's disease  
 
Structure map
Agents for Alzheimer-type dementia
Other DBs
CAS: 
425386-60-3
PubChem: 
LigandBox: 
KCF data Show

ATOM        26
            1   C1y C    27.3700  -23.8000
            2   C5x C    28.4900  -22.8900
            3   N1y N    29.8200  -23.2400
            4   C1x C    30.4500  -24.5000
            5   C8y C    27.3700  -25.2000
            6   C1x C    29.8200  -25.7600
            7   C8y C    28.4900  -26.0400
            8   N1b N    26.1800  -23.1000
            9   C5a C    24.9900  -23.8000
            10  C1c C    23.8000  -23.1000
            11  N1b N    22.6100  -23.8000
            12  C8x C    26.1100  -25.8300
            13  C8x C    26.1100  -27.2300
            14  C8x C    27.2300  -28.0000
            15  C8x C    28.4900  -27.3700
            16  O5a O    24.9900  -25.2000
            17  O5x O    28.4900  -21.4900
            18  C1a C    31.0100  -22.5400
            19  C5a C    21.3919  -23.1099
            20  C1c C    20.2105  -23.8050
            21  O5a O    21.3919  -21.7099
            22  C1c C    19.0051  -23.1221
            23  O1a O    20.2220  -25.2000
            24  C1a C    17.8339  -23.8109
            25  C1a C    19.0630  -21.7008
            26  C1a C    23.8000  -21.7000
BOND        27
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 2
            6     1   2 1
            7     6   7 1
            8     1   8 1 #Down
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    5  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15   7 1
            17    9  16 2
            18    2  17 2
            19   18   3 1
            20   11  19 1
            21   19  20 1
            22   19  21 2
            23   20  22 1
            24   20  23 1 #Up
            25   22  24 1
            26   22  25 1
            27   10  26 1 #Up

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