KEGG   DRUG: D09539Help
Entry
D09539                      Drug                                   

Name
Gabapentin enacarbil (JAN/USAN/INN);
Horizant (TN)
Product
Formula
C16H27NO6
Exact mass
329.1838
Mol weight
329.3887
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of neuropathic pain and restless legs syndrome
Remark
Drug group: 
Comment
prodrug, active substance: Gabapentin [DR:D00332]
Target
calcium channel, CACN alpha-2 delta blocker  [HSA:781 9254 55799 93589] [KO:K04858 K04859 K04860 K04861]
  Pathway
hsa04010  MAPK signaling pathway  
 
Interaction
Drug interaction
Structure map
Anticonvulsants
Brite
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Gabapentin
    D09539  Gabapentin enacarbil (JAN/USAN/INN)
 Central Nervous System Agents
  Central Nervous System, Other
   Gabapentin enacarbil
    D09539  Gabapentin enacarbil (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    voltage-dependent calcium channel
     Gabapentin
      D09539  Gabapentin enacarbil (JAN/USAN/INN)
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        23
            1   C1z C    25.9000  -23.5200
            2   C1b C    25.9000  -22.1200
            3   C1x C    25.9000  -24.9200
            4   C1x C    24.7100  -22.8200
            5   C6a C    27.0900  -21.4200
            6   C1x C    24.7100  -25.6200
            7   C1x C    23.4500  -23.5200
            8   O6a O    27.0900  -20.0900
            9   O6a O    28.2800  -22.1900
            10  C1x C    23.4500  -24.9200
            11  C1b C    27.0900  -24.2200
            12  N1b N    28.2800  -23.5200
            13  C7a C    29.4700  -24.2200
            14  O7a O    30.6600  -23.5200
            15  O6a O    29.4700  -25.6200
            16  C1c C    31.8500  -24.2200
            17  O7a O    33.0400  -23.5200
            18  C1a C    31.8500  -25.6200
            19  C7a C    34.2300  -24.2200
            20  C1c C    35.4200  -23.5200
            21  O6a O    34.2300  -25.6200
            22  C1a C    36.6100  -24.2200
            23  C1a C    35.4200  -22.1200
BOND        23
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    7  10 1
            11    1  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   13  15 2
            16   14  16 1
            17   16  17 1
            18   16  18 1
            19   17  19 1
            20   19  20 1
            21   19  21 2
            22   20  22 1
            23   20  23 1

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