KEGG   DRUG: D09572Help
Entry
D09572                      Drug                                   

Name
Riociguat (JAN/INN)
Product
Formula
C20H19FN8O2
Exact mass
422.1615
Mol weight
422.4157
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
guanylate cyclase activator
Remark
Therapeutic category: 
Target
soluble guanylate cyclase activator [HSA:2977 2982 2983] [KO:K12318 K12319]
  Pathway
hsa00230  Purine metabolism
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Brite
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Riociguat
    D09572  Riociguat (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D09572  Riociguat (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases
   soluble guanylate cyclase
    Riociguat
     D09572  Riociguat (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
625115-55-1
PubChem: 
LigandBox: 
KCF data Show

ATOM        31
            1   N5x N    13.4400  -16.3800
            2   C8y C    13.4400  -17.7800
            3   N5x N    14.6300  -18.4800
            4   C8y C    15.8900  -17.7800
            5   C8y C    15.8900  -16.3800
            6   C8y C    14.6300  -15.6800
            7   N1a N    14.6300  -14.2800
            8   N1c N    17.0800  -15.6800
            9   N1a N    17.0800  -18.4800
            10  C7a C    18.2700  -16.3800
            11  O7a O    19.4600  -15.6800
            12  O6a O    18.2700  -17.7800
            13  C1a C    20.6500  -16.3800
            14  C1a C    17.0800  -14.2800
            15  C8y C    12.2500  -18.4800
            16  N4y N    10.0100  -18.5500
            17  C8y C    10.4300  -19.8100
            18  C8y C    11.8300  -19.8100
            19  N5x N    11.1300  -17.6400
            20  N5x N     9.8000  -21.0700
            21  C8x C    10.5000  -22.2600
            22  C8x C    11.9000  -22.2600
            23  C8x C    12.6000  -21.0000
            24  C1b C     8.8200  -17.8500
            25  C8y C     7.6300  -18.5500
            26  C8x C     6.4400  -17.8500
            27  C8x C     5.1800  -18.5500
            28  C8x C     5.1800  -19.9500
            29  C8x C     6.3700  -20.6500
            30  C8y C     7.6300  -19.9500
            31  X   F     8.8200  -20.6500
BOND        34
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     6   7 1
            8     5   8 1
            9     4   9 1
            10    8  10 1
            11   10  11 1
            12   10  12 2
            13   11  13 1
            14    8  14 1
            15    2  15 1
            16   16  17 1
            17   17  18 2
            18   18  15 1
            19   15  19 2
            20   16  19 1
            21   17  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   24  16 1
            27   24  25 1
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   25  30 2
            34   30  31 1

» Japanese version   » Back

DBGET integrated database retrieval system