KEGG   DRUG: D09574Help
Entry
D09574                      Drug                                   
Name
Aflibercept (genetical recombination) (JAN);
Aflibercept (USAN/INN);
Ziv-aflibercept;
Eylea (TN);
Zaltrap (TN)
Product
Formula
C4318H6788N1164O1304S32
Exact mass
96837.1694
Mol weight
96897.1957
Sequence
SDTGRPFVEM YSEIPEIIHM TEGRELVIPC RVTSPNITVT LKKFPLDTLI PDGKRIIWDS
RKGFIISNAT YKEIGLLTCE ATVNGHLYKT NYLTHRQTNT IIDVVLSPSH GIELSVGEKL
VLNCTARTEL NVGIDFNWEY PSSKHQHKKL VNRDLKTQSG SEMKKFLSTL TIDGVTRSDQ
GLYTCAASSG LMTKKNSTFV RVHEKDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR
TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN
GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS
DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH
YTQKSLSLSP G
(Disulfide bridge: 30-79; 124-185; 246-306; 352-410, Dimer: 211; 214)
  Type
Peptide
Activity
Inhibitor of aberrant angiogenesis-vascular leak and inflammation;
angiogenesis inhibitor for treatment of cancer
Remark
Therapeutic category: 
ATC code: 
Comment
fusion protein
VEGF-Trap
Target
VEGF [HSA:7422 7423] [KO:K05448 K16858];
placental growth factor [HSA:5228] [KO:K16859]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D09574  Aflibercept (genetical recombination) (JAN); Aflibercept (USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01L OCULAR VASCULAR DISORDER AGENTS
    S01LA Antineovascularisation agents
     S01LA05 Aflibercept
      D09574  Aflibercept (genetical recombination) (JAN); Aflibercept (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  PDGF family
   PGF [HSA:5228] [KO:K05448]
    Aflibercept [ATC:S01LA05]
     D09574  Aflibercept (genetical recombination) (JAN); Aflibercept (USAN/INN)
   VEGFA [HSA:7422] [KO:K05448]
    Aflibercept [ATC:S01LA05]
     D09574  Aflibercept (genetical recombination) (JAN); Aflibercept (USAN/INN)
   VEGFB [HSA:7423] [KO:K05449]
    Aflibercept [ATC:S01LA05]
     D09574  Aflibercept (genetical recombination) (JAN); Aflibercept (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
862111-32-8
PubChem: 

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