KEGG   DRUG: D09589Help
Entry
D09589                      Drug                                   

Name
Brivanib (USAN)
Formula
C19H19FN4O3
Exact mass
370.1441
Mol weight
370.3776
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticancer
Comment
angiogenesis inhibitor
Target
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
fibroblast growth factor receptor 1 (FGFR1) inhibitor [HSA:2260] [KO:K04362];
fibroblast growth factor receptor 2 (FGFR2) inhibitor [HSA:2263] [KO:K05093]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04810  Regulation of actin cytoskeleton  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class IV (FGF receptor family)
    fibroblast growth factor receptor 1 [HSA:2260] [KO:K04362]
     Brivanib
      D09589  Brivanib (USAN)
    fibroblast growth factor receptor 2 [HSA:2263] [KO:K05093]
     Brivanib
      D09589  Brivanib (USAN)
   RTK class V (VEGF receptor family)
    VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
     Brivanib
      D09589  Brivanib (USAN)
BRITE hierarchy
Other DBs
CAS: 
649735-46-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8y C    20.0343  -24.4505
            2   C8y C    20.0343  -25.8516
            3   C8x C    21.2477  -26.5522
            4   C8x C    22.4612  -25.8516
            5   C8y C    22.4612  -24.4505
            6   C8y C    21.2477  -23.7499
            7   C8x C    18.7017  -24.0175
            8   C8y C    17.8781  -25.1511
            9   N4x N    18.7017  -26.2846
            10  X   F    21.2477  -22.3489
            11  O2a O    23.6934  -23.7389
            12  C8y C    23.6931  -22.3488
            13  C8y C    24.8946  -21.6547
            14  N4y N    24.8943  -20.2535
            15  N5x N    23.6807  -19.5532
            16  C8x C    22.4792  -20.2473
            17  N5x N    22.4795  -21.6485
            18  C8y C    26.2273  -22.0874
            19  C8y C    27.0506  -20.9536
            20  C8x C    26.2268  -19.8201
            21  O2a O    28.4414  -20.9532
            22  C1b C    29.1441  -19.7353
            23  C1c C    30.5430  -19.7349
            24  O1a O    31.2534  -20.9643
            25  C1a C    31.2341  -18.5375
            26  C1a C    26.6520  -23.3946
            27  C1a C    16.4613  -25.1511
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    2   9 1
            11    6  10 1
            12    5  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   12  17 2
            20   13  18 2
            21   18  19 1
            22   19  20 2
            23   14  20 1
            24   19  21 1
            25   21  22 1
            26   22  23 1
            27   23  24 1
            28   23  25 1 #Up
            29   18  26 1
            30    8  27 1

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