KEGG   DRUG: D09612Help
Entry
D09612                      Drug                                   

Name
Eslicarbazepine acetate (USAN);
Zebinix (TN);
Aptiom (TN)
Product
Formula
C17H16N2O3
Exact mass
296.1161
Mol weight
296.3205
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Adjunctive therapy for adults with partial-onset seizures
Remark
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
  Pathway
hsa04728  Dopaminergic synapse  
 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF04 Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Eslicarbazepine
    D09612  Eslicarbazepine acetate (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
    voltage-gated sodium channel (SCN2A)
     Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
    voltage-gated sodium channel (SCN3A)
     Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
    voltage-gated sodium channel (SCN4A)
     Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
    voltage-gated sodium channel (SCN5A)
     Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
    voltage-gated sodium channel (SCN8A)
     Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
    voltage-gated sodium channel (SCN9A)
     Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN)
BRITE hierarchy
Other DBs
CAS: 
236395-14-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        22
            1   C8y C    22.4000  -25.4100
            2   N1y N    23.6600  -24.7800
            3   C8y C    24.9200  -25.4100
            4   C8y C    25.2000  -26.7400
            5   C8y C    22.1200  -26.8100
            6   C1x C    24.3600  -27.8600
            7   C1y C    22.9600  -27.8600
            8   C8x C    21.3500  -24.4300
            9   C8x C    20.0200  -24.9200
            10  C8x C    19.7400  -26.2500
            11  C8x C    20.7900  -27.2300
            12  C8x C    26.6000  -27.0900
            13  C8x C    27.5800  -26.1100
            14  C8x C    27.2300  -24.7800
            15  C8x C    25.8300  -24.3600
            16  C5a C    23.6600  -23.3800
            17  O5a O    22.4700  -22.6800
            18  N1a N    24.8500  -22.6800
            19  O7a O    22.3300  -29.1200
            20  C7a C    20.9300  -29.1200
            21  O6a O    20.2300  -27.9076
            22  C1a C    20.2300  -30.3324
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1
            21    7  19 1 #Down
            22   19  20 1
            23   20  21 2
            24   20  22 1

» Japanese version   » Back

DBGET integrated database retrieval system