KEGG   DRUG: D09615Help
Entry
D09615                      Drug                                   

Name
Fezakinumab (USAN/INN)
Formula
C6408H9874N1706O2016S44
Exact mass
144389.0276
Mol weight
144478.0458
Sequence
(Heavy chain) QVQLVQSGAE VKKPGASVKV SCKASGYTFT NYYMHWVRQA
PGQGLEWVGW INPYTGSAFY AQKFRGRVTM TRDTSISTAY MELSRLRSDD TAVYYCAREP
EKFDSDDSDV WGRGTLVTVS SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV
SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKKVE
PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN
WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI
SKAKGQPREP QVYTLPPSRE EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP
VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG
(Disulfide bridge: 22-96; 148-204; 265-325; 371-429, Dimer: 230; 233)
(Light chain) QAVLTQPPSV SGAPGQRVTI SCTGSSSNIG AGYGVHWYQQ
LPGTAPKLLI YGDSNRPSGV PDRFSGSKSG TSASLAITGL QAEDEADYYC QSYDNSLSGY
VFGGGTQLTV LGQPKAAPSV TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV
KAGVETTTPS KQSNNKYAAS SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(Disulfide bridge: 22-90; 139-198; H224-L216)
  Type
Peptide
Activity
Treatment of inflammatory diseases
Comment
Monoclonal antibody
Target
IL-22 [HSA:50616] [KO:K05445]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class II cytokines
   IL-22
    Fezakinumab
     D09615  Fezakinumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1007106-86-6
PubChem: 

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