KEGG   DRUG: D09618Help
Entry
D09618                      Drug                                   

Name
Foretinib (USAN/INN)
Formula
C34H34F2N4O6
Exact mass
632.2446
Mol weight
632.6538
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic
Target
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
met proto-oncogene (c-Met) inhibitor [HSA:4233] [KO:K05099]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class V (VEGF receptor family)
    VEGFR2 tyrosine kinase
     Foretinib
      D09618  Foretinib (USAN/INN)
 Protein kinases
  Tyrosine protein kinases
   Met family
    MET
     Foretinib
      D09618  Foretinib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
849217-64-7
PubChem: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        46
            1   C8y C    24.2900  -30.1000
            2   C8y C    24.2900  -31.5000
            3   C8x C    25.4800  -32.2000
            4   C8y C    26.7400  -31.5000
            5   C8x C    26.7400  -30.1000
            6   C8x C    25.4800  -29.4000
            7   N1b N    27.9300  -32.2000
            8   C5a C    29.1200  -31.5000
            9   C1z C    30.3100  -32.2000
            10  O5a O    29.1200  -30.1000
            11  C5a C    31.5000  -31.5000
            12  N1b N    32.6900  -32.2000
            13  O5a O    31.5000  -30.1000
            14  C8y C    33.8800  -31.5000
            15  C8x C    35.0700  -32.2000
            16  C8x C    36.3300  -31.5000
            17  C8y C    36.3300  -30.1000
            18  C8x C    35.1400  -29.4000
            19  C8x C    33.8800  -30.1000
            20  X   F    23.1000  -32.2000
            21  O2a O    23.1000  -29.4000
            22  C8y C    21.9100  -30.1000
            23  C8y C    20.7200  -29.4000
            24  C8y C    19.4600  -30.1000
            25  N5x N    19.4600  -31.5000
            26  C8x C    20.6500  -32.2000
            27  C8x C    21.9100  -31.5000
            28  C8x C    20.7200  -28.0000
            29  C8y C    19.4600  -27.3000
            30  C8y C    18.2700  -28.0000
            31  C8x C    18.2700  -29.4000
            32  O2a O    17.0800  -27.3000
            33  C1b C    15.8900  -28.0000
            34  O2a O    19.4600  -25.9000
            35  C1b C    14.7000  -27.3000
            36  C1b C    13.5100  -28.0000
            37  N1y N    12.3200  -27.3000
            38  C1x C    12.3200  -25.9000
            39  C1x C    11.0600  -25.2000
            40  O2x O     9.8700  -25.9000
            41  C1x C     9.8700  -27.3000
            42  C1x C    11.0600  -28.0000
            43  C1a C    18.2700  -25.2000
            44  X   F    37.5200  -29.4000
            45  C1x C    29.6100  -33.3900
            46  C1x C    31.0100  -33.3900
BOND        51
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 2
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21    2  20 1
            22    1  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   26  27 1
            29   22  27 2
            30   23  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   24  31 1
            35   30  32 1
            36   32  33 1
            37   29  34 1
            38   33  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   38  39 1
            43   39  40 1
            44   40  41 1
            45   41  42 1
            46   37  42 1
            47   34  43 1
            48   17  44 1
            49   45  46 1
            50   46   9 1
            51    9  45 1

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