KEGG   DRUG: ForetinibHelp
Entry
D09618                      Drug                                   

Name
Foretinib (USAN/INN)
Formula
C34H34F2N4O6
Exact mass
632.2446
Mol weight
632.6538
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Activity
Antineoplastic, Angiogenesis inhibitor, Tyrosine kinase inhibitor
Target
VEGFR2 (KDR) [HSA:3791] [KO:K05098];
MET [HSA:4233] [KO:K05099]
  Pathway
Cytokine-cytokine receptor interaction
VEGF signaling pathway
Focal adhesion
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class V (VEGF receptor family)
    VEGFR2 tyrosine kinase
     Foretinib
      D09618  Foretinib (USAN/INN)
 Protein kinases
  Tyrosine protein kinases
   Met family
    MET
     Foretinib
      D09618  Foretinib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
849217-64-7
PubChem: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        46
            1   C8y C    24.2900  -30.1000
            2   C8y C    24.2900  -31.5000
            3   C8x C    25.4800  -32.2000
            4   C8y C    26.7400  -31.5000
            5   C8x C    26.7400  -30.1000
            6   C8x C    25.4800  -29.4000
            7   N1b N    27.9300  -32.2000
            8   C5a C    29.1200  -31.5000
            9   C1z C    30.3100  -32.2000
            10  O5a O    29.1200  -30.1000
            11  C5a C    31.5000  -31.5000
            12  N1b N    32.6900  -32.2000
            13  O5a O    31.5000  -30.1000
            14  C8y C    33.8800  -31.5000
            15  C8x C    35.0700  -32.2000
            16  C8x C    36.3300  -31.5000
            17  C8y C    36.3300  -30.1000
            18  C8x C    35.1400  -29.4000
            19  C8x C    33.8800  -30.1000
            20  X   F    23.1000  -32.2000
            21  O2a O    23.1000  -29.4000
            22  C8y C    21.9100  -30.1000
            23  C8y C    20.7200  -29.4000
            24  C8y C    19.4600  -30.1000
            25  N5x N    19.4600  -31.5000
            26  C8x C    20.6500  -32.2000
            27  C8x C    21.9100  -31.5000
            28  C8x C    20.7200  -28.0000
            29  C8y C    19.4600  -27.3000
            30  C8y C    18.2700  -28.0000
            31  C8x C    18.2700  -29.4000
            32  O2a O    17.0800  -27.3000
            33  C1b C    15.8900  -28.0000
            34  O2a O    19.4600  -25.9000
            35  C1b C    14.7000  -27.3000
            36  C1b C    13.5100  -28.0000
            37  N1y N    12.3200  -27.3000
            38  C1x C    12.3200  -25.9000
            39  C1x C    11.0600  -25.2000
            40  O2x O     9.8700  -25.9000
            41  C1x C     9.8700  -27.3000
            42  C1x C    11.0600  -28.0000
            43  C1a C    18.2700  -25.2000
            44  X   F    37.5200  -29.4000
            45  C1x C    29.6100  -33.3900
            46  C1x C    31.0100  -33.3900
BOND        51
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 2
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21    2  20 1
            22    1  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   26  27 1
            29   22  27 2
            30   23  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   24  31 1
            35   30  32 1
            36   32  33 1
            37   29  34 1
            38   33  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   38  39 1
            43   39  40 1
            44   40  41 1
            45   41  42 1
            46   37  42 1
            47   34  43 1
            48   17  44 1
            49   45  46 1
            50   46   9 1
            51    9  45 1

» Japanese version   » Back

DBGET integrated database retrieval system