KEGG   DRUG: D09631Help
Entry
D09631                      Drug                                   

Name
Intetumumab (USAN/INN)
Formula
C6468H10008N1744O2006S40
Exact mass
145488.3555
Mol weight
145577.7523
Sequence
(Heavy chain) QVQLVESGGG VVQPGRSRRL SCAASGFTFS RYTMHWVRQA
PGKGLEWVAV ISFDGSNKYY VDSVKGRFTI SRDNSENTLY LQVNILRAED TAVYYCAREA
RGSYAFDIWG QGTMVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW
NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK
SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY
VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK
AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: 22-96; 146-202; 263-323; 369-427, Dimer: 228; 231)
(Light chain) EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP
GQAPRLLIYD ASNRATGIPA RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPPFTFG
PGTKVDIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: 23-88; 135-195; H222-L215)
  Type
Peptide
Activity
Treatment of solid tumors
Comment
Monoclonal antibody
Target
integrin alpha V [HSA:3685] [KO:K06487]
  Pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04514  Cell adhesion molecules (CAMs)  
 
Brite
Target-based classification of drugs [BR:br08310]
 Others
  Cellular antigens
   CD51 (integrin alpha V)
    Intetumumab
     D09631  Intetumumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
725735-28-4
PubChem: 

» Japanese version   » Back

DBGET integrated database retrieval system