KEGG   DRUG: D09633Help
Entry
D09633                      Drug                                   

Name
Lebrikizumab (USAN/INN)
Formula
C6434H9972N1700O2034S50
Exact mass
145195.5169
Mol weight
145285.4411
Sequence
(Heavy chain) QVTLRESGPA LVKPTQTLTL TCTVSGFSLS AYSVNWIRQP
PGKALEWLAM IWGDGKIVYN SALKSRLTIS KDTSKNQVVL TMTNMDPVDT ATYYCAGDGY
YPYAMDNWGQ GSLVTVSSAS TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN
SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTKTYT CNVDHKPSNT KVDKRVESKY
GPPCPPCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV
EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ
PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG
SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGK
(Disulfide bridge: 22-95; 145-201; 259-319; 365-423, Dimer: 224; 227)
(Light chain) DIVMTQSPDS LSVSLGERAT INCRASKSVD SYGNSFMHWY
QQKPGQPPKL LIYLASNLES GVPDRFSGSG SGTDFTLTIS SLQAEDVAVY YCQQNNEDPR
TFGGGTKVEI KRTVAAPSVF IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS
GNSQESVTEQ DSKDSTYSLS STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: 23-92; 138-198; H132-L218)
  Type
Peptide
Comment
Monoclonal antibody
Target
IL-13 [HSA:3596] [KO:K05435]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05310  Asthma  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class I cytokines
   IL-13
    Lebrikizumab
     D09633  Lebrikizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
953400-68-5
PubChem: 

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