KEGG   DRUG: LinifanibHelp
Entry
D09635                      Drug                                   

Name
Linifanib (USAN/INN)
Formula
C21H18FN5O
Exact mass
375.1495
Mol weight
375.3989
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Activity
Antineoplastic
Comment
angiogenesis inhibitor
Target
VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097];
PDGFRA tyrosine kinase [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase [HSA:5159] [KO:K05089];
CSF1 [HSA:1435] [KO:K05453]
  Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
VEGF signaling pathway
Focal adhesion
Gap junction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Linifanib
      D09635  Linifanib (USAN/INN)
    PDGFRB tyrosine kinase
     Linifanib
      D09635  Linifanib (USAN/INN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Linifanib
      D09635  Linifanib (USAN/INN)
    VEGFR2 tyrosine kinase
     Linifanib
      D09635  Linifanib (USAN/INN)
    VEGFR3 tyrosine kinase
     Linifanib
      D09635  Linifanib (USAN/INN)
 Cytokines
  PDGF family
   CSF1
    Linifanib
     D09635  Linifanib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
796967-16-3
PubChem: 
LigandBox: 
KCF data Show

ATOM        28
            1   C8x C    13.5100  -21.4200
            2   C8y C    13.5100  -22.8200
            3   C8x C    14.7224  -23.5200
            4   C8x C    15.9349  -22.8200
            5   C8y C    15.9349  -21.4200
            6   C8x C    14.7224  -20.7200
            7   N1b N    17.1660  -20.7090
            8   C5a C    18.3712  -21.4047
            9   N1b N    19.5535  -20.7219
            10  O5a O    18.3716  -22.8196
            11  C8y C    20.7475  -21.4112
            12  C8y C    20.7476  -22.8197
            13  C8x C    21.9601  -23.5196
            14  C8x C    23.1725  -22.8195
            15  C8y C    23.1723  -21.4109
            16  C8x C    21.9598  -20.7111
            17  X   F    19.5146  -23.5321
            18  C1a C    24.3790  -20.7141
            19  C8y C    12.2976  -23.5200
            20  C8y C    11.1021  -22.8296
            21  C8y C     9.8896  -23.5295
            22  C8x C     9.8894  -24.9295
            23  C8x C    11.0849  -25.6199
            24  C8x C    12.2974  -24.9200
            25  C8y C    10.8111  -21.4602
            26  N5x N     9.4188  -21.3137
            27  N4x N     8.8493  -22.5926
            28  N1a N    11.7192  -20.4518
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 2
            11    9  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   12  17 1
            19   15  18 1
            20    2  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   19  24 1
            27   20  25 1
            28   25  26 2
            29   26  27 1
            30   21  27 1
            31   25  28 1

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