KEGG   DRUG: D09637Help
Entry
D09637                      Drug                                   

Name
Lomitapide (USAN/INN)
Formula
C39H37F6N3O2
Exact mass
693.279
Mol weight
693.7204
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hypercholesterolemia and hypertriglyceridemia
Remark
ATC code: 
Target
microsomal triglyceride transfer protein (MTP) inhibitor [HSA:4547] [KO:K14463]
  Pathway
hsa04975  Fat digestion and absorption  
 
Interaction
Genomic biomarker: LDLR [HSA:3949]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AX Other lipid modifying agents
     C10AX12 Lomitapide
      D09637  Lomitapide (USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Other
   Lomitapide
    D09637  Lomitapide (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
182431-12-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        50
            1   C8y C    14.3500  -34.9300
            2   C8y C    14.7700  -36.2600
            3   C8y C    16.1700  -36.2600
            4   C8y C    16.5900  -34.9300
            5   C1z C    15.4700  -34.0900
            6   C8x C    17.0800  -37.3100
            7   C8x C    18.4800  -37.0300
            8   C8x C    18.9000  -35.7000
            9   C8x C    17.9900  -34.6500
            10  C8x C    12.9500  -34.5800
            11  C8x C    12.0400  -35.6300
            12  C8x C    12.4600  -36.9600
            13  C8x C    13.7900  -37.3100
            14  C5a C    14.2800  -33.3900
            15  N1b N    13.0900  -34.0900
            16  O5a O    14.2800  -31.9900
            17  C1b C    11.9000  -33.3900
            18  C1d C    10.7100  -34.0900
            19  X   F     9.5200  -33.3900
            20  X   F    10.7100  -35.4900
            21  X   F     9.5200  -34.7900
            22  C1b C    16.6600  -33.3900
            23  C1b C    17.8500  -34.0900
            24  C1b C    19.0400  -33.3900
            25  C1b C    20.2300  -34.0900
            26  N1y N    21.4200  -33.3900
            27  C1x C    22.6381  -34.0801
            28  C1x C    23.8448  -33.3703
            29  C1y C    23.9034  -31.9703
            30  C1x C    22.6153  -31.2802
            31  C1x C    21.4086  -31.9900
            32  N1b N    25.0857  -31.2957
            33  C5a C    26.2728  -31.9893
            34  C8y C    27.4712  -31.3055
            35  O5a O    26.2657  -33.3899
            36  C8y C    28.6501  -31.9941
            37  C8x C    29.8660  -31.3003
            38  C8x C    29.8732  -29.9003
            39  C8x C    28.6944  -29.2117
            40  C8x C    27.4084  -29.9055
            41  C8y C    28.6429  -33.3899
            42  C8x C    27.4172  -34.0893
            43  C8x C    27.4100  -35.4893
            44  C8y C    28.6189  -36.1955
            45  C8x C    29.8446  -35.4961
            46  C8x C    29.8517  -34.0961
            47  C1d C    28.6118  -37.5899
            48  X   F    28.6047  -38.9898
            49  X   F    30.0118  -37.5899
            50  X   F    27.2118  -37.5899
BOND        55
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     3   6 2
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    4   9 2
            11    1  10 2
            12   10  11 1
            13   11  12 2
            14   12  13 1
            15    2  13 2
            16   14   5 1
            17   14  15 1
            18   14  16 2
            19   15  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1
            23   18  21 1
            24   22  23 1
            25   22   5 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   26  31 1
            35   29  32 1
            36   32  33 1
            37   33  34 1
            38   33  35 2
            39   34  36 2
            40   36  37 1
            41   37  38 2
            42   38  39 1
            43   39  40 2
            44   34  40 1
            45   36  41 1
            46   41  42 2
            47   42  43 1
            48   43  44 2
            49   44  45 1
            50   45  46 2
            51   41  46 1
            52   44  47 1
            53   47  48 1
            54   47  49 1
            55   47  50 1

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