KEGG   DRUG: D09638Help
Entry
D09638                      Drug                                   

Name
Lomitapide mesylate (USAN);
Juxtapid (TN)
Product
Formula
C39H37F6N3O2. CH4SO3
Exact mass
789.2671
Mol weight
789.8261
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hypercholesterolemia and hypertriglyceridemia
Remark
ATC code: 
Target
microsomal triglyceride transfer protein (MTP) inhibitor [HSA:4547] [KO:K14463]
  Pathway
hsa04975  Fat digestion and absorption  
 
Interaction
Genomic biomarker: LDLR [HSA:3949]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AX Other lipid modifying agents
     C10AX12 Lomitapide
      D09638  Lomitapide mesylate (USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Other
   Lomitapide
    D09638  Lomitapide mesylate (USAN)
BRITE hierarchy
Other DBs
CAS: 
202914-84-9
PubChem: 
LigandBox: 
KCF data Show

ATOM        55
            1   C1a C    33.9659  -22.7313
            2   S4a S    35.3691  -22.7313
            3   O1d O    36.7724  -22.7313
            4   O1d O    35.3691  -21.3281
            5   O1d O    35.3691  -24.1345
            6   C8y C    15.7257  -23.3680
            7   C8y C    16.1467  -24.7013
            8   C8y C    17.5502  -24.7013
            9   C8y C    17.9712  -23.3680
            10  C1z C    16.8485  -22.5259
            11  C8x C    18.4625  -25.7539
            12  C8x C    19.8659  -25.4732
            13  C8x C    20.2870  -24.1399
            14  C8x C    19.3747  -23.0873
            15  C8x C    14.3222  -23.0171
            16  C8x C    13.4100  -24.0698
            17  C8x C    13.8310  -25.4031
            18  C8x C    15.1643  -25.7539
            19  C5a C    15.6555  -21.8242
            20  N1b N    14.4626  -22.5259
            21  O5a O    15.6555  -20.4207
            22  C1b C    13.2696  -21.8242
            23  C1d C    12.0767  -22.5259
            24  X   F    10.8837  -21.8242
            25  X   F    12.0767  -23.9294
            26  X   F    10.8837  -23.2277
            27  C1b C    18.0414  -21.8242
            28  C1b C    19.2344  -22.5259
            29  C1b C    20.4273  -21.8242
            30  C1b C    21.6203  -22.5259
            31  N1y N    22.8132  -21.8242
            32  C1x C    24.0062  -22.5259
            33  C1x C    25.2693  -21.8242
            34  C1y C    25.2693  -20.4207
            35  C1x C    24.0062  -19.7190
            36  C1x C    22.8132  -20.4207
            37  N1b N    26.4623  -19.7190
            38  C5a C    27.6552  -20.4207
            39  C8y C    28.8482  -19.7190
            40  O5a O    27.6552  -21.8242
            41  C8y C    30.0411  -20.4207
            42  C8x C    31.3042  -19.7190
            43  C8x C    31.3042  -18.3155
            44  C8x C    30.1113  -17.6138
            45  C8x C    28.8482  -18.3155
            46  C8y C    30.0411  -21.8242
            47  C8x C    28.8482  -22.5259
            48  C8x C    28.8482  -23.9294
            49  C8y C    30.0411  -24.6311
            50  C8x C    31.2341  -23.9294
            51  C8x C    31.2341  -22.5259
            52  C1d C    30.0411  -26.0346
            53  X   F    30.0411  -27.4381
            54  X   F    31.4446  -26.0346
            55  X   F    28.6376  -26.0346
BOND        59
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     2   5 2
            5     6   7 1
            6     7   8 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14    9  14 2
            15    6  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19    7  18 2
            20   19  10 1
            21   19  20 1
            22   19  21 2
            23   20  22 1
            24   22  23 1
            25   23  24 1
            26   23  25 1
            27   23  26 1
            28   27  28 1
            29   27  10 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   31  32 1
            34   32  33 1
            35   33  34 1
            36   34  35 1
            37   35  36 1
            38   31  36 1
            39   34  37 1
            40   37  38 1
            41   38  39 1
            42   38  40 2
            43   39  41 2
            44   41  42 1
            45   42  43 2
            46   43  44 1
            47   44  45 2
            48   39  45 1
            49   41  46 1
            50   46  47 2
            51   47  48 1
            52   48  49 2
            53   49  50 1
            54   50  51 2
            55   46  51 1
            56   49  52 1
            57   52  53 1
            58   52  54 1
            59   52  55 1

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