KEGG   DRUG: D09659Help
Entry
D09659                      Drug                                   

Name
Rilotumumab (USAN/INN)
Formula
C6464H9932N1708O2010S46
Exact mass
145115.4623
Mol weight
145205.2525
Sequence
(Heavy chain) QVQLQESGPG LVKPSETLSL TCTVSGGSIS IYYWSWIRQP
PGKGLEWIGY VYYSGSTNYN PSLKSRVTIS VDTSKNQFSL KLNSVTAADT AVYYCARGGY
DFWSGYFDYW GQGTLVTVSS ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS
WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER
KCCVECPPCP APPVAGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG
VEVHNAKTKP REEQFNSTFR VVSVLTVVHQ DWLNGKEYKC KVSNKGLPAP IEKTISKTKG
QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPMLDSD
GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Disulfide bridge: 22-95; 147-203; 260-320; 366-424, Dimer: 222; 223; 226; 229)
(Light chain) EIVMTQSPAT LSVSPGERAT LSCRASQSVD SNLAWYRQKP
GQAPRLLIYG ASTRATGIPA RFSGSGSGTE FTLTISSLQS EDFAVYYCQQ YINWPPITFG
QGTRLEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: 23-88; 135-195; H134-L215)
  Type
Peptide
Activity
Oncology, solid tumors
Comment
Monoclonal antibody
Target
HGF [HSA:3082] [KO:K05460]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04510  Focal adhesion
hsa05200  Pathways in cancer  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  PDGF family
   HGF [HSA:3082] [KO:K05460]
    Rilotumumab
     D09659  Rilotumumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
872514-65-3
PubChem: 

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