KEGG   DRUG: D09662Help
Entry
D09662                      Drug                                   

Name
Rontalizumab (USAN/INN)
Formula
C6486H9990N1722O2026S44
Exact mass
145825.9336
Mol weight
145915.9026
Sequence
(Heavy chain) EVQLVESGGG LVQPGGSLRL SCATSGYTFT EYIIHWVRQA
PGKGLEWVAS INPDYDITNY NQRFKGRFTI SLDKSKRTAY LQMNSLRAED TAVYYCASWI
SDFFDYWGQG TLVTVSSAST KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS
GALTSGVHTF PAVLQSSGLY SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKKVEPKSC
DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD
GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK
GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS
DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Disulfide bridge: 22-96; 144-200; 261-321; 367-425, Dimer: 226; 229)
(Light chain) DIQMTQSPSS LSASVGDRVT ITCRASQSVS TSSYSYMHWY
QQKPGKAPKV LISYASNLES GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQHSWGIPR
TFGQGTKVEI KRTVAAPSVF IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS
GNSQESVTEQ DSKDSTYSLS STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: 23-92; 138-198; H220-L218)
  Type
Peptide
Activity
Treatment of systemic lupus erythematosus (SLE)
Comment
Monoclonal antibody
Target
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04140  Regulation of autophagy
hsa04630  Jak-STAT signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  Class II cytokines
   interferon alpha
    Rontalizumab
     D09662  Rontalizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
948570-30-7
PubChem: 

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